| Title |
Epidemiology and outcome of acute lung injury in European intensive care units
|
|---|---|
| Published in |
Intensive Care Medicine, January 2004
|
| DOI | 10.1007/s00134-003-2022-6 |
| Pubmed ID | |
| Authors |
Christian Brun-Buisson, Cosetta Minelli, Guido Bertolini, Luca Brazzi, Jorge Pimentel, Klaus Lewandowski, Julian Bion, Jacques-André Romand, Jesús Villar, Adalbjörn Thorsteinsson, Pierre Damas, Apostolos Armaganidis, François Lemaire |
| Abstract |
To re-examine the epidemiology of acute lung injury (ALI) in European intensive care units (ICUs). A 2-month inception cohort study in 78 ICUs of 10 European countries. All patients admitted for more than 4 h were screened for ALI and followed up to 2 months. Acute lung injury occurred in 463 (7.1%) of 6,522 admissions and 16.1% of all mechanically ventilated patients; 65.4% cases occurred on ICU admission. Among 136 patients initially presenting with "mild ALI" (200< PaO2/FiO2 < or =300), 74 (55%) evolved to acute respiratory distress syndrome (ARDS) within 3 days. Sixty-two patients (13.4%) remained with mild ALI and 401 had ARDS. The crude ICU and hospital mortalities were 22.6% and 32.7% (p<0.001), and 49.4% and 57.9% (p=0.0005), respectively, for mild ALI and ARDS. ARDS patients initially received a mean tidal volume of 8.3+/-1.9 ml/kg and a mean PEEP of 7.7+/-3.6 cmH2O; air leaks occurred in 15.9%. After multivariate analysis, mortality was associated with age (odds ratio (OR) =1.2 per 10 years; 95% confidence interval (CI): 1.05-1.36), immuno-incompetence (OR: 2.88; Cl: 1.57-5.28), the severity scores SAPS II (OR: 1.16 per 10% expected mortality; Cl: 1.02-1.31) and logistic organ dysfunction (OR: 1.25 per point; Cl: 1.13-1.37), a pH less than 7.30 (OR: 1.88; Cl: 1.11-3.18) and early air leak (OR: 3.16; Cl: 1.59-6.28). Acute lung injury was frequent in our sample of European ICUs (7.1%); one third of patients presented with mild ALI, but more than half rapidly evolved to ARDS. While the mortality of ARDS remains high, that of mild ALI is twice as low, confirming the grading of severity between the two forms of the syndrome. |
Mendeley readers
The data shown below were compiled from readership statistics for 296 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 3 | 1% |
| United States | 3 | 1% |
| Italy | 2 | <1% |
| Germany | 2 | <1% |
| United Kingdom | 2 | <1% |
| Australia | 1 | <1% |
| Colombia | 1 | <1% |
| Greece | 1 | <1% |
| Iran, Islamic Republic of | 1 | <1% |
| Other | 0 | 0% |
| Unknown | 280 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 44 | 15% |
| Student > Ph. D. Student | 34 | 11% |
| Student > Doctoral Student | 33 | 11% |
| Student > Master | 29 | 10% |
| Professor > Associate Professor | 26 | 9% |
| Other | 86 | 29% |
| Unknown | 44 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 179 | 60% |
| Agricultural and Biological Sciences | 18 | 6% |
| Engineering | 13 | 4% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 2% |
| Biochemistry, Genetics and Molecular Biology | 5 | 2% |
| Other | 20 | 7% |
| Unknown | 55 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 September 2023.
All research outputs
#2,712,998
of 22,881,154 outputs
Outputs from Intensive Care Medicine
#1,772
of 4,993 outputs
Outputs of similar age
#7,330
of 133,379 outputs
Outputs of similar age from Intensive Care Medicine
#3
of 31 outputs
Altmetric has tracked 22,881,154 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,993 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.2. This one has gotten more attention than average, scoring higher than 64% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 133,379 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 31 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.