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BMI1 expression identifies subtypes of Merkel cell carcinoma

Overview of attention for article published in Virchows Archiv, October 2012
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Title
BMI1 expression identifies subtypes of Merkel cell carcinoma
Published in
Virchows Archiv, October 2012
DOI 10.1007/s00428-012-1327-7
Pubmed ID
Authors

Maria Kouzmina, Valtteri Häyry, Junnu Leikola, Caj Haglund, Tom Böhling, Virve Koljonen, Jaana Hagström

Abstract

Merkel cell carcinoma (MCC) is a rare cutaneous neuroendocrine carcinoma. The aims of this study were to investigate the expression of the transcription factors B-lymphoma Moloney murine leukaemia virus insertion (BMI1), myelocytomatosis viral oncogene homologue (c-Myc) and Snail in MCC tumour specimens and to examine the relationship of these markers to Merkel cell polyoma virus (MCV). The study comprised of 133 patients with primary MCC. The expression of BMI1, Snail and c-Myc protein was assessed by immunohistochemistry and compared with clinical parameters, MCV status and patient survival. The presence of MCV was inversely correlated with the expression of BMI1 protein. Tumours expressing BMI1 protein more often presented with lymph node metastases. Snail protein expression was decreased in cases with metastatic dissemination. This study identified two subgroups of MCC: tumours expressing BMI1 but negative for MCV DNA and tumours negative for BMI1 expression but positive for MCV. Importantly, BMI1-positive cases often presented with lymph node metastases. Combined, these results suggest that subtypes of this malignancy exist.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 11 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 11 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 4 36%
Student > Ph. D. Student 3 27%
Professor > Associate Professor 2 18%
Student > Bachelor 1 9%
Unknown 1 9%
Readers by discipline Count As %
Medicine and Dentistry 4 36%
Agricultural and Biological Sciences 4 36%
Biochemistry, Genetics and Molecular Biology 1 9%
Unknown 2 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 October 2012.
All research outputs
#17,645,959
of 22,681,577 outputs
Outputs from Virchows Archiv
#1,423
of 1,934 outputs
Outputs of similar age
#125,207
of 172,686 outputs
Outputs of similar age from Virchows Archiv
#11
of 25 outputs
Altmetric has tracked 22,681,577 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,934 research outputs from this source. They receive a mean Attention Score of 4.0. This one is in the 26th percentile – i.e., 26% of its peers scored the same or lower than it.
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We're also able to compare this research output to 25 others from the same source and published within six weeks on either side of this one. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.