| Title |
Losartan therapy in adults with Marfan syndrome: study protocol of the multi-center randomized controlled COMPARE trial
|
|---|---|
| Published in |
Trials, January 2010
|
| DOI | 10.1186/1745-6215-11-3 |
| Pubmed ID | |
| Authors |
Teodora Radonic, Piet de Witte, Marieke JH Baars, Aeilko H Zwinderman, Barbara JM Mulder, Maarten Groenink, COMPARE study group |
| Abstract |
Marfan syndrome (MFS) is one of the most common systemic disorders of connective tissue with the incidence of approximately 2-3 per 10 000 individuals. Aortic disease, leading to progressive aneurysmal dilatation and dissection is the main cause of morbidity and mortality of Marfan patients. Current treatment (e.g. beta blockers and elective surgery) does postpone but cannot prevent aortic complications in these patients. Recent studies have found transforming growth factor beta (TGF beta) to be involved in the aortic aneurysm formation. Losartan, an angiotensin II type 1 receptor blocker inhibits TGFbeta in a mouse model of Marfan syndrome leading to inhibition of aortic growth. The main objective of this trial is to assess whether losartan treatment leads to a clinically relevant decrease of aortic dilatation in adult patients with Marfan syndrome. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 76 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | 1% |
| Sweden | 1 | 1% |
| United Kingdom | 1 | 1% |
| Canada | 1 | 1% |
| New Zealand | 1 | 1% |
| United States | 1 | 1% |
| Unknown | 70 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 13 | 17% |
| Student > Ph. D. Student | 11 | 14% |
| Student > Master | 11 | 14% |
| Student > Bachelor | 7 | 9% |
| Other | 6 | 8% |
| Other | 15 | 20% |
| Unknown | 13 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 40 | 53% |
| Agricultural and Biological Sciences | 9 | 12% |
| Nursing and Health Professions | 3 | 4% |
| Psychology | 3 | 4% |
| Biochemistry, Genetics and Molecular Biology | 1 | 1% |
| Other | 4 | 5% |
| Unknown | 16 | 21% |