| Title |
Acute Toxicity Associated with Use of 5F-Derivations of Synthetic Cannabinoid Receptor Agonists with Analytical Confirmation
|
|---|---|
| Published in |
Journal of Medical Toxicology, July 2016
|
| DOI | 10.1007/s13181-016-0571-7 |
| Pubmed ID | |
| Authors |
Rachelle Abouchedid, James H. Ho, Simon Hudson, Alison Dines, John R. H. Archer, David M. Wood, Paul I. Dargan |
| Abstract |
Synthetic Cannabinoid Receptor Agonists (SCRAs) are the largest group of new psychoactive substances reported to the European Warning System and the United Nations Office on Drugs and Crime to date. The heterogeneous nature and speed of diversification of these compounds make it challenging to accurately characterise and predict harms of these compounds in pre-clinical studies, ahead of their appearance. We report the case of a 19-year-old female who purchased three products from a headshop: two new psychoactive substances (sachets of "cannabis tea" and "mushroom tea") as well as two LSD blotters. After the "cannabis tea" was smoked and the two LSD blotters and "mushroom tea" were ingested, the patient became tachycardic (HR 128), developed seizures, agitation, visual hallucinations as well as suspected serotonergic toxicity (sustained ankle clonus 20-30 beats) 1-2 hours after use. She was treated with 1 mg of intravenous midazolam. Symptoms/signs resolved within 13 hours. No further supportive care was required. Plasma, blood, and urine samples confirmed the presence of two SCRAs: 5FAKB-48 and 5F-PB-22. The patient also reported therapeutic use of both fluoxetine and citalopram for depression. To the best of our knowledge, this is the first case report of non-fatal intoxication with 5F-AKB-48 with analytical confirmation and exposure times. It also highlights the difficulties in understanding the pattern of toxicity of certain SCRAs in the context of psychotropic medications/co-morbid mental illness. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Norway | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 118 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 118 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 22 | 19% |
| Student > Ph. D. Student | 15 | 13% |
| Student > Master | 13 | 11% |
| Researcher | 10 | 8% |
| Other | 6 | 5% |
| Other | 16 | 14% |
| Unknown | 36 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 33 | 28% |
| Psychology | 9 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 5% |
| Nursing and Health Professions | 5 | 4% |
| Agricultural and Biological Sciences | 4 | 3% |
| Other | 20 | 17% |
| Unknown | 41 | 35% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 December 2023.
All research outputs
#7,199,777
of 23,482,849 outputs
Outputs from Journal of Medical Toxicology
#419
of 682 outputs
Outputs of similar age
#120,504
of 367,964 outputs
Outputs of similar age from Journal of Medical Toxicology
#10
of 17 outputs
Altmetric has tracked 23,482,849 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 682 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 17.4. This one is in the 36th percentile – i.e., 36% of its peers scored the same or lower than it.
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We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.