| Title |
Blood–brain barrier P-glycoprotein function in healthy subjects and Alzheimer's disease patients: effect of polymorphisms in the ABCB1 gene
|
|---|---|
| Published in |
EJNMMI Research, October 2012
|
| DOI | 10.1186/2191-219x-2-57 |
| Pubmed ID | |
| Authors |
Daniëlle ME van Assema, Mark Lubberink, Patrizia Rizzu, John C van Swieten, Robert C Schuit, Jonas Eriksson, Philip Scheltens, Matthias Koepp, Adriaan A Lammertsma, Bart NM van Berckel |
| Abstract |
P-glycoprotein is a blood-brain barrier efflux transporter involved in the clearance of amyloid-beta from the brain and, as such, might be involved in the pathogenesis of Alzheimer's disease. P-glycoprotein is encoded by the highly polymorphic ABCB1 gene. Single-nucleotide polymorphisms in the ABCB1 gene have been associated with altered P-glycoprotein expression and function. P-glycoprotein function at the blood-brain barrier can be quantified in vivo using the P-glycoprotein substrate tracer (R)-[11C]verapamil and positron emission tomography (PET). The purpose of this study was to assess the effects of C1236T, G2677T/A and C3435T single-nucleotide polymorphisms in ABCB1 on blood-brain barrier P-glycoprotein function in healthy subjects and patients with Alzheimer's disease. |
Mendeley readers
The data shown below were compiled from readership statistics for 67 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 1% |
| Portugal | 1 | 1% |
| Germany | 1 | 1% |
| Unknown | 64 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 15 | 22% |
| Student > Master | 13 | 19% |
| Student > Ph. D. Student | 11 | 16% |
| Student > Bachelor | 7 | 10% |
| Other | 4 | 6% |
| Other | 8 | 12% |
| Unknown | 9 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 11 | 16% |
| Biochemistry, Genetics and Molecular Biology | 11 | 16% |
| Pharmacology, Toxicology and Pharmaceutical Science | 8 | 12% |
| Agricultural and Biological Sciences | 7 | 10% |
| Neuroscience | 5 | 7% |
| Other | 13 | 19% |
| Unknown | 12 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 October 2012.
All research outputs
#22,758,309
of 25,373,627 outputs
Outputs from EJNMMI Research
#442
of 612 outputs
Outputs of similar age
#172,341
of 192,616 outputs
Outputs of similar age from EJNMMI Research
#5
of 13 outputs
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So far Altmetric has tracked 612 research outputs from this source. They receive a mean Attention Score of 2.9. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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