| Title |
Pseudomembranous colitis: isolation of two species of cytotoxic clostridia and successful treatment with vancomycin.
|
|---|---|
| Published in |
Canadian Medical Association Journal, November 1978
|
| Pubmed ID | |
| Authors |
T J Marrie, R S Faulkner, B W Badley, M R Hartlen, S A Comeau, H R Miller |
| Abstract |
Lincomycin-resistant Clostridium sporogenes obtained from the stools of a patient with lincomycin-associated pseudomembranous colitis produced a heat-stable cytotoxin in low titre when grown in chopped meat medium. Vancomycin eradicated this strain and all other clostridia, and controlled the symptoms. When diarrhea recurred 7 days after treatment with vancomycin was stopped, clostridia including C. sporogenes and C. difficile were again isolated. The C. difficile produced a heat-labile cytotoxin in high titre that was unaffected by growth in various media and induced colitis in hamsters. Treatment with vancomycin, to which all the clostridia were sensitive, eradicated both toxic species and controlled the diarrhea. Antibiotic-induced pseudomembranous colitis may be associated with more than one species of toxin-producing clostridia. Vancomycin therapy should be continued for 10 days or more in patients with severe disease to eradicate the responsible organism. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 8 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 8 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Professor > Associate Professor | 2 | 25% |
| Professor | 2 | 25% |
| Student > Postgraduate | 2 | 25% |
| Other | 1 | 13% |
| Unspecified | 1 | 13% |
| Other | 0 | 0% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 2 | 25% |
| Agricultural and Biological Sciences | 1 | 13% |
| Unspecified | 1 | 13% |
| Physics and Astronomy | 1 | 13% |
| Immunology and Microbiology | 1 | 13% |
| Other | 0 | 0% |
| Unknown | 2 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 February 2021.
All research outputs
#22,764,772
of 25,382,440 outputs
Outputs from Canadian Medical Association Journal
#9,098
of 9,453 outputs
Outputs of similar age
#5,384
of 5,565 outputs
Outputs of similar age from Canadian Medical Association Journal
#6
of 7 outputs
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