| Title |
Effect of a new bioactive fibrous glassy scaffold on bone repair
|
|---|---|
| Published in |
Journal of Materials Science: Materials in Medicine, April 2015
|
| DOI | 10.1007/s10856-015-5516-1 |
| Pubmed ID | |
| Authors |
P. R. Gabbai-Armelin, M. T. Souza, H. W. Kido, C. R. Tim, P. S. Bossini, A. M. P. Magri, K. R. Fernandes, F. A. C. Pastor, E. D. Zanotto, N. A. Parizotto, O. Peitl, A. C. M. Renno |
| Abstract |
Researchers have investigated several therapeutic approaches to treat non-union fractures. Among these, bioactive glasses and glass ceramics have been widely used as grafts. This class of biomaterial has the ability to integrate with living bone. Nevertheless, bioglass and bioactive materials have been used mainly as powder and blocks, compromising the filling of irregular bone defects. Considering this matter, our research group has developed a new bioactive glass composition that can originate malleable fibers, which can offer a more suitable material to be used as bone graft substitutes. Thus, the aim of this study was to assess the morphological structure (via scanning electron microscope) of these fibers upon incubation in phosphate buffered saline (PBS) after 1, 7 and 14 days and, also, evaluate the in vivo tissue response to the new biomaterial using implantation in rat tibial defects. The histopathological, immunohistochemistry and biomechanical analyzes after 15, 30 and 60 days of implantation were performed to investigate the effects of the material on bone repair. The PBS incubation indicated that the fibers of the glassy scaffold degraded over time. The histological analysis revealed a progressive degradation of the material with increasing implantation time and also its substitution by granulation tissue and woven bone. Histomorphometry showed a higher amount of newly formed bone area in the control group (CG) compared to the biomaterial group (BG) 15 days post-surgery. After 30 and 60 days, CG and BG showed a similar amount of newly formed bone. The novel biomaterial enhanced the expression of RUNX-2 and RANK-L, and also improved the mechanical properties of the tibial callus at day 15 after surgery. These results indicated a promising use of the new biomaterial for bone engineering. However, further long-term studies should be carried out to provide additional information concerning the material degradation in the later stages and the bone regeneration induced by the fibrous material. |
Mendeley readers
The data shown below were compiled from readership statistics for 72 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 72 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 23 | 32% |
| Student > Ph. D. Student | 9 | 13% |
| Researcher | 8 | 11% |
| Student > Doctoral Student | 6 | 8% |
| Student > Bachelor | 4 | 6% |
| Other | 8 | 11% |
| Unknown | 14 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 15 | 21% |
| Materials Science | 14 | 19% |
| Engineering | 12 | 17% |
| Chemistry | 5 | 7% |
| Chemical Engineering | 2 | 3% |
| Other | 6 | 8% |
| Unknown | 18 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 December 2016.
All research outputs
#3,799,947
of 22,881,154 outputs
Outputs from Journal of Materials Science: Materials in Medicine
#83
of 1,403 outputs
Outputs of similar age
#48,824
of 264,848 outputs
Outputs of similar age from Journal of Materials Science: Materials in Medicine
#2
of 17 outputs
Altmetric has tracked 22,881,154 research outputs across all sources so far. Compared to these this one has done well and is in the 82nd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,403 research outputs from this source. They receive a mean Attention Score of 3.4. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 264,848 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 81% of its contemporaries.
We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.