You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
Fluoride incorporation in high phosphate containing bioactive glasses and in vitro osteogenic, angiogenic and antibacterial effects
|
|---|---|
| Published in |
Dental Materials, July 2016
|
| DOI | 10.1016/j.dental.2016.07.003 |
| Pubmed ID | |
| Authors |
Jie Liu, Simon C.F. Rawlinson, Robert G. Hill, Farida Fortune |
| Abstract |
To manufacture and assess bioactivity of low fluoride/high phosphate (low F(-)/high P2O5) bioglasses (BGs). Then the effects of BG-conditioned medium on osteoblast-like cell behavior and BG particles on bactericidal activity were investigated. BGs (0-7% F(-) content, constant 6.33% P2O5 in mol%) were designed and produced. BG particles was immersed in Tris Buffer solution or α-MEM to determine apatite formation and ion (Ca, P, Si and F) release. Osteoblast-like cells MC3T3-E1 were treated with BG-conditioned medium and assessed for cytotoxicity, pre-osteogenic and pro-angiogenic responses. Antibacterial ability was explored by incubating sub-gingival bacteria with BG particulates. Rapid apatite formation was observed in F(-) containing BGs after only 2-8h immersion in Tris buffer solution. In the F(-) free group, apatite was not detectable until 72h. Peak Ca, P and F release into Tris buffer was at 2h immersion, and then the levels decreased. In α-MEM, apatite formation in all the BGs was undetectable until 72h immersion. Alkaline phosphatase activity, cell number, collagen formation, bone-like mineral nodules and osteogenic gene expression of MC3T3-E1 cells were significantly promoted in low F(-) BG (P6.33F1) conditioned medium. MC3T3-E1 VEGF gene expression was increased, and protein production was dose-dependently promoted with F(-) BG-conditioned medium. After incubation with BG particulates, the growth of sub-gingival bacteria, Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis, was significantly inhibited; the antibacterial activity being dependent on the F(-) content of the BGs. These results show that low F(-)/high P2O5 BGs significantly accelerated apatite formation and promoted both pre-osteogenic and pro-angiogenic responses of MC3T3-E1 osteoblast-like cells and inhibited the growth of periodontal pathogens in vitro. These BGs may prove useful as bone graft substitutes. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 73 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | 1% |
| Unknown | 72 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 14 | 19% |
| Student > Master | 9 | 12% |
| Student > Postgraduate | 6 | 8% |
| Student > Bachelor | 5 | 7% |
| Researcher | 4 | 5% |
| Other | 9 | 12% |
| Unknown | 26 | 36% |
| Readers by discipline | Count | As % |
|---|---|---|
| Materials Science | 13 | 18% |
| Medicine and Dentistry | 13 | 18% |
| Engineering | 5 | 7% |
| Biochemistry, Genetics and Molecular Biology | 4 | 5% |
| Chemical Engineering | 2 | 3% |
| Other | 5 | 7% |
| Unknown | 31 | 42% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 July 2016.
All research outputs
#22,758,309
of 25,373,627 outputs
Outputs from Dental Materials
#957
of 1,087 outputs
Outputs of similar age
#337,844
of 379,928 outputs
Outputs of similar age from Dental Materials
#6
of 14 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,087 research outputs from this source. They receive a mean Attention Score of 3.7. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 379,928 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.