Chapter title |
Curcumin as a MicroRNA Regulator in Cancer: A Review
|
---|---|
Chapter number | 3 |
Book title |
Reviews of Physiology, Biochemistry and Pharmacology, Vol. 171
|
Published in |
Reviews of Physiology, Biochemistry and Pharmacology, July 2016
|
DOI | 10.1007/112_2016_3 |
Pubmed ID | |
Book ISBNs |
978-3-31-943813-9, 978-3-31-943814-6
|
Authors |
Momtazi, Amir Abbas, Shahabipour, Fahimeh, Khatibi, Sepideh, Johnston, Thomas P, Pirro, Matteo, Sahebkar, Amirhossein, Amir Abbas Momtazi, Fahimeh Shahabipour, Sepideh Khatibi, Thomas P. Johnston, Matteo Pirro, Amirhossein Sahebkar |
Editors |
Bernd Nilius, Pieter de Tombe, Thomas Gudermann, Reinhard Jahn, Roland Lill, Ole H. Petersen |
Abstract |
Curcumin is a natural dietary polyphenol for which anti-tumor effects have been documented. Anti-inflammatory and antioxidant properties of curcumin, along with its immunomodulatory, proapoptotic, and antiangiogenic properties, are often referred to as the main mechanisms underlying the anti-tumor effects. At the molecular level, inhibition of NF-kB, Akt/PI3K, and MAPK pathways and enhancement of p53 are among the most important anticancer alterations induced by curcumin. Recent evidence has suggested that epigenetic alterations are also involved in the anti-tumor properties of curcumin. Among these curcumin-induced epigenetic alterations is modulation of the expression of several oncogenic and tumor suppressor microRNAs (miRNAs). Suppression of oncomiRs such as miR-21, miR-17-5p, miR-20a, and miR-27a and over-expression of miR-34 a/c and epithelial-mesenchymal transition-suppressor miRNAs are among the most important effects of curcumin on miRNA homeostasis. The present review will summarize the findings of in vitro and experimental studies on the impact of curcumin and its analogues on the expression of miRNAs involved in different stages of tumor initiation, growth, metastasis, and chemo-resistance. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 50% |
France | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 95 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 15 | 16% |
Student > Bachelor | 12 | 13% |
Student > Master | 9 | 9% |
Researcher | 8 | 8% |
Student > Doctoral Student | 6 | 6% |
Other | 14 | 15% |
Unknown | 31 | 33% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 15 | 16% |
Pharmacology, Toxicology and Pharmaceutical Science | 12 | 13% |
Medicine and Dentistry | 9 | 9% |
Agricultural and Biological Sciences | 7 | 7% |
Chemistry | 4 | 4% |
Other | 14 | 15% |
Unknown | 34 | 36% |