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The Dynamics of Naturally Acquired Immunity to Plasmodium falciparum Infection

Overview of attention for article published in PLoS Computational Biology, October 2012
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  • Above-average Attention Score compared to outputs of the same age and source (51st percentile)

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4 X users
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2 Facebook pages

Citations

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46 Dimensions

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143 Mendeley
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Title
The Dynamics of Naturally Acquired Immunity to Plasmodium falciparum Infection
Published in
PLoS Computational Biology, October 2012
DOI 10.1371/journal.pcbi.1002729
Pubmed ID
Authors

Mykola Pinkevych, Janka Petravic, Kiprotich Chelimo, James W. Kazura, Ann M. Moormann, Miles P. Davenport

Abstract

Severe malaria occurs predominantly in young children and immunity to clinical disease is associated with cumulative exposure in holoendemic settings. The relative contribution of immunity against various stages of the parasite life cycle that results in controlling infection and limiting disease is not well understood. Here we analyse the dynamics of Plasmodium falciparum malaria infection after treatment in a cohort of 197 healthy study participants of different ages in order to model naturally acquired immunity. We find that both delayed time-to-infection and reductions in asymptomatic parasitaemias in older age groups can be explained by immunity that reduces the growth of blood stage as opposed to liver stage parasites. We found that this mechanism would require at least two components - a rapidly acting strain-specific component, as well as a slowly acquired cross-reactive or general immunity to all strains. Analysis and modelling of malaria infection dynamics and naturally acquired immunity with age provides important insights into what mechanisms of immune control may be harnessed by malaria vaccine strategists.

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X Demographics

The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 143 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Tanzania, United Republic of 1 <1%
France 1 <1%
Brazil 1 <1%
United Kingdom 1 <1%
Denmark 1 <1%
Spain 1 <1%
United States 1 <1%
Philippines 1 <1%
Unknown 135 94%

Demographic breakdown

Readers by professional status Count As %
Student > Master 27 19%
Student > Ph. D. Student 26 18%
Researcher 24 17%
Student > Bachelor 19 13%
Student > Doctoral Student 9 6%
Other 15 10%
Unknown 23 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 42 29%
Biochemistry, Genetics and Molecular Biology 20 14%
Medicine and Dentistry 20 14%
Immunology and Microbiology 12 8%
Computer Science 6 4%
Other 14 10%
Unknown 29 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 December 2020.
All research outputs
#8,572,103
of 25,461,852 outputs
Outputs from PLoS Computational Biology
#5,649
of 8,981 outputs
Outputs of similar age
#65,943
of 193,902 outputs
Outputs of similar age from PLoS Computational Biology
#51
of 109 outputs
Altmetric has tracked 25,461,852 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 8,981 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.4. This one is in the 33rd percentile – i.e., 33% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 193,902 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 109 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.