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Treatment Practices and Outcomes After Blunt Cerebrovascular Injury in Children

Overview of attention for article published in Neurosurgery, December 2016
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Title
Treatment Practices and Outcomes After Blunt Cerebrovascular Injury in Children
Published in
Neurosurgery, December 2016
DOI 10.1227/neu.0000000000001352
Pubmed ID
Authors

Michael C. Dewan, Vijay M. Ravindra, Stephen Gannon, Colin T. Prather, George L. Yang, Lori C. Jordan, David Limbrick, Andrew Jea, Jay Riva-Cambrin, Robert P. Naftel

Abstract

Pediatric blunt cerebrovascular injury (BCVI) lacks accepted treatment algorithms, and postinjury outcomes are ill defined. To compare treatment practices among pediatric trauma centers and to describe outcomes for available treatment modalities. Clinical and radiographic data were collected from a patient cohort with BCVI between 2003 and 2013 at 4 academic pediatric trauma centers. Among 645 pediatric patients evaluated with computed tomography angiography for BCVI, 57 vascular injuries (82% carotid artery, 18% vertebral artery) were diagnosed in 52 patients. Grade I (58%) and II (23%) injuries accounted for most lesions. Severe intracranial or intra-abdominal hemorrhage precluded antithrombotic therapy in 10 patients. Among the remaining patients, primary therapy was an antiplatelet agent in 14 (33%), anticoagulation in 8 (19%), endovascular intervention in 3 (7%), open surgery in 1 (2%), and no treatment in 16 (38%). Among 27 eligible grade I injuries, 16 (59%) were not treated, and the choice to not treat varied significantly among centers (P < .001). There were no complications from medical management. Glasgow Coma Scale (GCS) score <8 and increasing injury grade were predictors of injury progression (P = .001 and .004, respectively). Poor GCS score (P = .02), increasing injury grade (P = .03), and concomitant intracranial injury (P = .02) correlated with increased risk of mortality. Treatment modality did not correlate with progression of vascular injury or mortality. Treatment of BCVI with antiplatelet or anticoagulant therapy is safe and may confer modest benefit. Nonmodifiable factors, including presenting GCS score, vascular injury grade, and additional intracranial injury, remain the most important predictors of poor outcome. ATT, antithrombotic therapyBCVI, blunt cerebrovascular injuryCTA, computed tomography angiographyGCS, Glasgow Coma Scale.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 38 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 38 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 8 21%
Student > Postgraduate 7 18%
Other 4 11%
Researcher 3 8%
Student > Ph. D. Student 3 8%
Other 6 16%
Unknown 7 18%
Readers by discipline Count As %
Medicine and Dentistry 22 58%
Neuroscience 2 5%
Biochemistry, Genetics and Molecular Biology 1 3%
Psychology 1 3%
Environmental Science 1 3%
Other 0 0%
Unknown 11 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 July 2016.
All research outputs
#22,758,309
of 25,373,627 outputs
Outputs from Neurosurgery
#5,296
of 5,705 outputs
Outputs of similar age
#356,624
of 416,449 outputs
Outputs of similar age from Neurosurgery
#54
of 58 outputs
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