| Title |
Lichen secondary metabolite evernic acid as potential quorum sensing inhibitor against Pseudomonasaeruginosa
|
|---|---|
| Published in |
World Journal of Microbiology and Biotechnology, July 2016
|
| DOI | 10.1007/s11274-016-2105-5 |
| Pubmed ID | |
| Authors |
Barış Gökalsın, Nüzhet Cenk Sesal |
| Abstract |
Cystic Fibrosis is a genetic disease and it affects the respiratory and digestive systems. Pseudomonas aeruginosa infections in Cystic Fibrosis are presented as the main cause for high mortality and morbidity rates. Pseudomonas aeruginosa populations can regulate their virulence gene expressions via the bacterial communication system: quorum sensing. Inhibition of quorum sensing by employing quorum sensing inhibitors can leave the bacteria vulnerable. Therefore, determining natural sources to obtain potential quorum sensing inhibitors is essential. Lichens have ethnobotanical value for their medicinal properties and it is possible that their secondary metabolites have quorum sensing inhibitor properties. This study aims to investigate an alternative treatment approach by utilizing lichen secondary metabolite evernic acid to reduce the expressions of Pseudomonas aeruginosa virulence factors by inhibiting quorum sensing. For this purpose, fluorescent monitor strains were utilized for quorum sensing inhibitor screens and quantitative reverse-transcriptase PCR analyses were conducted for comparison. Results indicate that evernic acid is capable of inhibiting Pseudomonas aeruginosa quorum sensing systems. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 43 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 43 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 9 | 21% |
| Student > Master | 6 | 14% |
| Researcher | 6 | 14% |
| Student > Ph. D. Student | 4 | 9% |
| Student > Doctoral Student | 3 | 7% |
| Other | 5 | 12% |
| Unknown | 10 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 7 | 16% |
| Biochemistry, Genetics and Molecular Biology | 7 | 16% |
| Chemistry | 5 | 12% |
| Agricultural and Biological Sciences | 5 | 12% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 7% |
| Other | 4 | 9% |
| Unknown | 12 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 May 2021.
All research outputs
#7,686,573
of 23,911,072 outputs
Outputs from World Journal of Microbiology and Biotechnology
#300
of 1,757 outputs
Outputs of similar age
#127,447
of 371,336 outputs
Outputs of similar age from World Journal of Microbiology and Biotechnology
#4
of 24 outputs
Altmetric has tracked 23,911,072 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 1,757 research outputs from this source. They receive a mean Attention Score of 2.9. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 371,336 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.
We're also able to compare this research output to 24 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 79% of its contemporaries.