Title |
Prevalence of Skin Cancer and Related Skin Tumors in High-Risk Kidney and Liver Transplant Recipients in Queensland, Australia
|
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Published in |
Journal of Investigative Dermatology, March 2016
|
DOI | 10.1016/j.jid.2016.02.804 |
Pubmed ID | |
Authors |
Michelle R. Iannacone, Sudipta Sinnya, Nirmala Pandeya, Nikky Isbel, Scott Campbell, Jonathan Fawcett, Peter H. Soyer, Lisa Ferguson, Marcia Davis, David C. Whiteman, Adèle C. Green, STAR Study, Scott Campbell, Daniel Chambers, Marcia Davis, Jonathan Fawcett, Lisa Ferguson, Michelle Grant, Adèle Green, Carmel Hawley, Peter Hopkins, Nicole Isbel, Michelle Iannacone, Therese Lawton, Diana Leary, Kyoko Miura, Tom Olsen, Nirmala Pandeya, Natalie Ong, Azadeh Sahebian, Sudipta Sinnya, H. Peter Soyer, Jean M. Tan, Mandy Way, David Whiteman |
Abstract |
The increased skin cancer incidence in organ transplant recipients (OTRs) is well-known, but the skin cancer burden at any one time is unknown. Our objective was to estimate the period prevalence of untreated skin malignancy and actinic keratoses (AKs) in high-risk kidney and liver transplant recipients and assess associated factors. OTRs underwent full skin examinations by dermatologically-trained physicians. The proportion of examined OTRs with histopathologically-confirmed skin cancer in the 3-month baseline period was estimated. Prevalence ratios (PR) with 95% confidence intervals (CIs) indicated significant associations. Of 495 high-risk OTRs (average age 54, immunosuppressed 8.9 years), 135 (27%) had basal cell carcinoma, squamous cell carcinoma or Bowen Disease (intra-epidermal carcinoma) present and confirmed in the baseline period with respective prevalence proportions of 10%, 11%, and 18% in kidney recipients and 10%, 9% and 13% in liver transplant recipients. Over 80% had AKs present with approximately 30% having >5AKs. OTRs with the highest skin cancer burden were Australian-born; fair-skinned (PR=1.61, 1.07-2.43); reported past skin cancer (PR=3.39, 95% CI=1.93-5.95); and were receiving the most frequent skin checks (PR=1.76, 95% CI=1.15-2.70). In conclusion, high-risk OTRs carry a substantial measurable skin cancer burden at any given time and require frequent review through easily accessible, specialized services. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
France | 1 | 14% |
Unknown | 6 | 86% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 5 | 71% |
Practitioners (doctors, other healthcare professionals) | 1 | 14% |
Science communicators (journalists, bloggers, editors) | 1 | 14% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 37 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 9 | 24% |
Other | 4 | 11% |
Professor | 2 | 5% |
Student > Master | 2 | 5% |
Student > Postgraduate | 2 | 5% |
Other | 5 | 14% |
Unknown | 13 | 35% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 13 | 35% |
Biochemistry, Genetics and Molecular Biology | 3 | 8% |
Nursing and Health Professions | 2 | 5% |
Business, Management and Accounting | 1 | 3% |
Psychology | 1 | 3% |
Other | 3 | 8% |
Unknown | 14 | 38% |