| Title |
Comparative Analysis of Breast Cancer Phenotypes in African American, White American, and West Versus East African patients: Correlation Between African Ancestry and Triple-Negative Breast Cancer
|
|---|---|
| Published in |
Annals of Surgical Oncology, July 2016
|
| DOI | 10.1245/s10434-016-5420-z |
| Pubmed ID | |
| Authors |
Evelyn Jiagge, Aisha Souleiman Jibril, Dhananjay Chitale, Jessica M. Bensenhaver, Baffour Awuah, Mark Hoenerhoff, Ernest Adjei, Mahteme Bekele, Engida Abebe, S. David Nathanson, Kofi Gyan, Barbara Salem, Joseph Oppong, Francis Aitpillah, Ishmael Kyei, Ernest Osei Bonsu, Erica Proctor, Sofia D. Merajver, Max Wicha, Azadeh Stark, Lisa A. Newman |
| Abstract |
Triple-negative breast cancer (TNBC) is more common among African American (AA) and western sub-Saharan African breast cancer (BC) patients compared with White/Caucasian Americans (WA) and Europeans. Little is known about TNBC in east Africa. Invasive BC diagnosed 1998-2014 were evaluated: WA and AA patients from the Henry Ford Health System in Detroit, Michigan; Ghanaian/west Africans from the Komfo Anokye Teaching Hospital in Kumasi, Ghana; and Ethiopian/east Africans from the St. Paul's Hospital Millennium Medical College in Addis Ababa, Ethiopia. Histopathology and immunohistochemistry for estrogen receptor (ER), progesterone receptor (PR), and HER2/neu expression was performed in Michigan on formalin-fixed, paraffin-embedded samples from all cases. A total of 234 Ghanaian (mean age 49 years), 94 Ethiopian (mean age 43 years), 272 AA (mean age 60 years), and 321 WA (mean age 62 years; p = 0.001) patients were compared. ER-negative and TNBC were more common among Ghanaian and AA compared with WA and Ethiopian cases (frequency ER-negativity 71.1 and 37.1 % vs. 19.8 and 28.6 % respectively, p < 0.0001; frequency TNBC 53.2 and 29.8 % vs. 15.5 and 15.0 %, respectively, p < 0.0001). Among patients younger than 50 years, prevalence of TNBC remained highest among Ghanaians (50.8 %) and AA (34.3 %) compared with WA and Ethiopians (approximately 16 % in each; p = 0.0002). This study confirms an association between TNBC and West African ancestry; TNBC frequency among AA patients is intermediate between WA and Ghanaian/West Africans consistent with genetic admixture following the west Africa-based trans-Atlantic slave trade. TNBC frequency was low among Ethiopians/East Africans; this may reflect less shared ancestry between AA and Ethiopians. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 91 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 91 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 12 | 13% |
| Student > Ph. D. Student | 11 | 12% |
| Student > Bachelor | 11 | 12% |
| Student > Postgraduate | 9 | 10% |
| Student > Master | 9 | 10% |
| Other | 18 | 20% |
| Unknown | 21 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 29 | 32% |
| Biochemistry, Genetics and Molecular Biology | 10 | 11% |
| Nursing and Health Professions | 5 | 5% |
| Agricultural and Biological Sciences | 4 | 4% |
| Social Sciences | 3 | 3% |
| Other | 13 | 14% |
| Unknown | 27 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 July 2016.
All research outputs
#18,466,751
of 22,881,964 outputs
Outputs from Annals of Surgical Oncology
#5,000
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Outputs of similar age
#282,201
of 365,664 outputs
Outputs of similar age from Annals of Surgical Oncology
#131
of 179 outputs
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