| Title |
Plasma Corin as a Predictor of Cardiovascular Events in Patients With Chronic Heart Failure
|
|---|---|
| Published in |
JACC: Heart Failure, May 2016
|
| DOI | 10.1016/j.jchf.2016.03.006 |
| Pubmed ID | |
| Authors |
Xiang Zhou, Jian-Chang Chen, Ying Liu, Hui Yang, Kang Du, Yuan Kong, Xiao-Hua Xu |
| Abstract |
The aim of this study was to determine the prognostic value of plasma corin in patients with chronic heart failure (CHF). In recent years, accumulating evidence has indicated that corin plays a critical role in regulating blood pressure and cardiac function. We enrolled 1,148 consecutive CHF patients in a prospective cohort study and explored the association between plasma corin levels and clinical prognosis using multivariate Cox regression analysis. Patients with low corin levels (< 458 pg/ml) were more likely to be women and to be hypertensive. Low corin was found to be associated with an increase in New York Heart Association (NYHA) functional class and N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels, and a decrease in left ventricular ejection fraction (LVEF) and the estimated glomerular filtration rate (eGFR). Multivariate Cox regression analysis suggested that log corin was an independent predictor of major adverse cardiac event(s) (MACE) (hazard ratio: 0.62; 95% confidence interval: 0.39 to 0.95), together with age, diabetes, NYHA functional class, LVEF, eGFR, and log NT-proBNP. In addition, log corin was also a significant predictor for cardiovascular death (p = 0.041) and heart failure rehospitalization (p = 0.015) after adjustment for clinical variables and established biomarkers of adverse prognosis. The Kaplan-Meier survival curves showed that low corin was a significant predictor of MACE in patients with NT-proBNP levels above and below the median. Our study demonstrates that plasma corin is a valuable prognostic marker of MACE in patients with CHF, independent of established conventional risk factors. |
X Demographics
The data shown below were collected from the profiles of 24 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 6 | 25% |
| Canada | 2 | 8% |
| Colombia | 1 | 4% |
| Ecuador | 1 | 4% |
| Spain | 1 | 4% |
| Netherlands | 1 | 4% |
| Mexico | 1 | 4% |
| Unknown | 11 | 46% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 19 | 79% |
| Scientists | 3 | 13% |
| Science communicators (journalists, bloggers, editors) | 1 | 4% |
| Practitioners (doctors, other healthcare professionals) | 1 | 4% |
Mendeley readers
The data shown below were compiled from readership statistics for 35 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 3% |
| Unknown | 34 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 8 | 23% |
| Researcher | 7 | 20% |
| Student > Postgraduate | 2 | 6% |
| Student > Master | 2 | 6% |
| Student > Ph. D. Student | 1 | 3% |
| Other | 3 | 9% |
| Unknown | 12 | 34% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 13 | 37% |
| Nursing and Health Professions | 3 | 9% |
| Biochemistry, Genetics and Molecular Biology | 2 | 6% |
| Sports and Recreations | 1 | 3% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 3% |
| Other | 2 | 6% |
| Unknown | 13 | 37% |
Attention Score in Context
This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 August 2019.
All research outputs
#2,779,166
of 25,371,288 outputs
Outputs from JACC: Heart Failure
#747
of 1,582 outputs
Outputs of similar age
#44,558
of 323,883 outputs
Outputs of similar age from JACC: Heart Failure
#17
of 46 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,582 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 30.2. This one has gotten more attention than average, scoring higher than 52% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 323,883 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 46 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.