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X Demographics
Mendeley readers
Attention Score in Context
| Title |
CD19 CAR immune pressure induces B-precursor acute lymphoblastic leukaemia lineage switch exposing inherent leukaemic plasticity
|
|---|---|
| Published in |
Nature Communications, July 2016
|
| DOI | 10.1038/ncomms12320 |
| Pubmed ID | |
| Authors |
Elad Jacoby, Sang M. Nguyen, Thomas J. Fountaine, Kathryn Welp, Berkley Gryder, Haiying Qin, Yinmeng Yang, Christopher D. Chien, Alix E. Seif, Haiyan Lei, Young K. Song, Javed Khan, Daniel W. Lee, Crystal L. Mackall, Rebecca A. Gardner, Michael C. Jensen, Jack F. Shern, Terry J. Fry |
| Abstract |
Adoptive immunotherapy using chimeric antigen receptor (CAR) expressing T cells targeting the CD19 B lineage receptor has demonstrated marked success in relapsed pre-B-cell acute lymphoblastic leukaemia (ALL). Persisting CAR-T cells generate sustained pressure against CD19 that may drive unique mechanisms of resistance. Pre-B ALL originates from a committed pre-B cell or an earlier progenitor, with potential to reprogram into other hematopoietic lineages. Here we report changes in lineage markers including myeloid conversion in patients following CD19 CAR therapy. Using murine ALL models we study the long-term effects of CD19 CAR-T cells and demonstrate partial or complete lineage switch as a consistent mechanism of CAR resistance depending on the underlying genetic oncogenic driver. Deletion of Pax5 or Ebf1 recapitulates lineage reprogramming occurring during CD19 CAR pressure. Our findings establish lineage switch as a mechanism of CAR resistance exposing inherent plasticity in genetic subtypes of pre-B-cell ALL. |
X Demographics
The data shown below were collected from the profiles of 20 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 12 | 60% |
| Italy | 1 | 5% |
| Saudi Arabia | 1 | 5% |
| United Kingdom | 1 | 5% |
| Comoros | 1 | 5% |
| Russia | 1 | 5% |
| Unknown | 3 | 15% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 11 | 55% |
| Practitioners (doctors, other healthcare professionals) | 4 | 20% |
| Scientists | 3 | 15% |
| Science communicators (journalists, bloggers, editors) | 2 | 10% |
Mendeley readers
The data shown below were compiled from readership statistics for 264 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 264 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 49 | 19% |
| Researcher | 48 | 18% |
| Student > Doctoral Student | 22 | 8% |
| Student > Master | 21 | 8% |
| Student > Bachelor | 15 | 6% |
| Other | 32 | 12% |
| Unknown | 77 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 54 | 20% |
| Biochemistry, Genetics and Molecular Biology | 39 | 15% |
| Agricultural and Biological Sciences | 36 | 14% |
| Immunology and Microbiology | 33 | 13% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 2% |
| Other | 18 | 7% |
| Unknown | 79 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 28. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 February 2024.
All research outputs
#1,423,992
of 26,017,215 outputs
Outputs from Nature Communications
#21,119
of 58,133 outputs
Outputs of similar age
#26,509
of 385,053 outputs
Outputs of similar age from Nature Communications
#330
of 830 outputs
Altmetric has tracked 26,017,215 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 58,133 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.5. This one has gotten more attention than average, scoring higher than 63% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 385,053 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 830 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.