| Title |
Potentiation of synaptic transmission in Rat anterior cingulate cortex by chronic itch
|
|---|---|
| Published in |
Molecular Brain, July 2016
|
| DOI | 10.1186/s13041-016-0251-1 |
| Pubmed ID | |
| Authors |
Ting-Ting Zhang, Feng-Yan Shen, Li-Qing Ma, Wen Wen, Bin Wang, Yuan-Zhi Peng, Zhi-Ru Wang, Xuan Zhao |
| Abstract |
Itch and pain share similar mechanisms. It has been well documented that the anterior cingulate cortex (ACC) is important for pain-related perception. ACC has also been approved to be a potential pruritus-associated brain region. However, the mechanism of sensitization in pruriceptive neurons in the ACC is not clear. In current study, a chronic itch model was established by diphenylcyclopropenone (DCP) application. We found that both the frequency and amplitude of miniature excitatory postsynaptic currents in the ACC were enhanced after the formation of chronic itch. The paired-pulse ratio in ACC neurons recorded from the DCP group were smaller than those recorded in control group at the 50-ms interval. We also observe a significant increase in the AMPA/NMDA ratio in the DCP group. Moreover, an increased inward rectification of AMPARs in ACC pyramidal neurons was observed in the DCP group. Interestingly, the calculated ratio of silent synapses was significantly reduced in the DCP group compared with controls. Taken together, we conclude that a potentiation of synaptic transmission in the ACC can be induced by chronic itch, and unsilencing silent synapses, which probably involved recruitment of AMPARS, contributed to the potentiation of postsynaptic transmission. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 22 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 3 | 14% |
| Researcher | 3 | 14% |
| Student > Master | 3 | 14% |
| Professor | 2 | 9% |
| Student > Bachelor | 1 | 5% |
| Other | 4 | 18% |
| Unknown | 6 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 8 | 36% |
| Biochemistry, Genetics and Molecular Biology | 3 | 14% |
| Medicine and Dentistry | 2 | 9% |
| Agricultural and Biological Sciences | 1 | 5% |
| Psychology | 1 | 5% |
| Other | 0 | 0% |
| Unknown | 7 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 August 2016.
All research outputs
#17,811,816
of 22,881,964 outputs
Outputs from Molecular Brain
#749
of 1,112 outputs
Outputs of similar age
#267,535
of 365,421 outputs
Outputs of similar age from Molecular Brain
#11
of 16 outputs
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