| Title |
The quest to make fully functional human pancreatic beta cells from embryonic stem cells: climbing a mountain in the clouds
|
|---|---|
| Published in |
Diabetologia, July 2016
|
| DOI | 10.1007/s00125-016-4059-4 |
| Pubmed ID | |
| Authors |
James D. Johnson |
| Abstract |
The production of fully functional insulin-secreting cells to treat diabetes is a major goal of regenerative medicine. In this article, I review progress towards this goal over the last 15 years from the perspective of a beta cell biologist. I describe the current state-of-the-art, and speculate on the general approaches that will be required to identify and achieve our ultimate goal of producing functional beta cells. The need for deeper phenotyping of heterogeneous cultures of stem cell derived islet-like cells in parallel with a better understanding of the heterogeneity of the target cell type(s) is emphasised. This deep phenotyping should include high-throughput single-cell analysis, as well as comprehensive 'omics technologies to provide unbiased characterisation of cell products and human beta cells. There are justified calls for more detailed and well-powered studies of primary human pancreatic beta cell physiology, and I propose online databases of standardised human beta cell responses to physiological stimuli, including both functional and metabolomic/proteomic/transcriptomic profiles. With a concerted, community-wide effort, including both basic and applied scientists, beta cell replacement will become a clinical reality for patients with diabetes. |
X Demographics
The data shown below were collected from the profiles of 32 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 8 | 25% |
| Canada | 7 | 22% |
| United Kingdom | 3 | 9% |
| Chile | 1 | 3% |
| Brazil | 1 | 3% |
| Unknown | 12 | 38% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 15 | 47% |
| Scientists | 13 | 41% |
| Practitioners (doctors, other healthcare professionals) | 3 | 9% |
| Science communicators (journalists, bloggers, editors) | 1 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 109 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Finland | 1 | <1% |
| Unknown | 108 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 31 | 28% |
| Researcher | 27 | 25% |
| Student > Master | 17 | 16% |
| Student > Bachelor | 11 | 10% |
| Student > Doctoral Student | 6 | 6% |
| Other | 9 | 8% |
| Unknown | 8 | 7% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 43 | 39% |
| Agricultural and Biological Sciences | 31 | 28% |
| Medicine and Dentistry | 13 | 12% |
| Engineering | 4 | 4% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 3% |
| Other | 4 | 4% |
| Unknown | 11 | 10% |
Attention Score in Context
This research output has an Altmetric Attention Score of 26. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 September 2019.
All research outputs
#1,496,857
of 25,732,188 outputs
Outputs from Diabetologia
#797
of 5,376 outputs
Outputs of similar age
#27,680
of 381,720 outputs
Outputs of similar age from Diabetologia
#19
of 82 outputs
Altmetric has tracked 25,732,188 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,376 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 24.7. This one has done well, scoring higher than 85% of its peers.
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We're also able to compare this research output to 82 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 76% of its contemporaries.