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X Demographics
Mendeley readers
| Title |
Transmission, infectivity, and antibody neutralization of an emerging SARS-CoV-2 variant in California carrying a L452R spike protein mutation
|
|---|---|
| Published in |
medRxiv, March 2021
|
| DOI | 10.1101/2021.03.07.21252647 |
| Pubmed ID | |
| Authors |
Xianding Deng, Miguel A Garcia-Knight, Mir M. Khalid, Venice Servellita, Candace Wang, Mary Kate Morris, Alicia Sotomayor-González, Dustin R Glasner, Kevin R Reyes, Amelia S. Gliwa, Nikitha P. Reddy, Claudia Sanchez San Martin, Scot Federman, Jing Cheng, Joanna Balcerek, Jordan Taylor, Jessica A Streithorst, Steve Miller, G. Renuka Kumar, Bharath Sreekumar, Pei-Yi Chen, Ursula Schulze-Gahmen, Taha Y. Taha, Jennifer Hayashi, Camille R. Simoneau, Sarah McMahon, Peter V. Lidsky, Yinghong Xiao, Peera Hemarajata, Nicole M. Green, Alex Espinosa, Chantha Kath, Monica Haw, John Bell, Jill K. Hacker, Carl Hanson, Debra A. Wadford, Carlos Anaya, Donna Ferguson, Liana F. Lareau, Phillip A. Frankino, Haridha Shivram, Stacia K. Wyman, Melanie Ott, Raul Andino, Charles Y. Chiu |
| Abstract |
We identified a novel SARS-CoV-2 variant by viral whole-genome sequencing of 2,172 nasal/nasopharyngeal swab samples from 44 counties in California. Named B.1.427/B.1.429 to denote its 2 lineages, the variant emerged around May 2020 and increased from 0% to >50% of sequenced cases from September 1, 2020 to January 29, 2021, exhibiting an 18.6-24% increase in transmissibility relative to wild-type circulating strains. The variant carries 3 mutations in the spike protein, including an L452R substitution. Our analyses revealed 2-fold increased B.1.427/B.1.429 viral shedding in vivo and increased L452R pseudovirus infection of cell cultures and lung organoids, albeit decreased relative to pseudoviruses carrying the N501Y mutation found in the B.1.1.7, B.1.351, and P.1 variants. Antibody neutralization assays showed 4.0 to 6.7-fold and 2.0-fold decreases in neutralizing titers from convalescent patients and vaccine recipients, respectively. The increased prevalence of a more transmissible variant in California associated with decreased antibody neutralization warrants further investigation. |
X Demographics
The data shown below were collected from the profiles of 299 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 67 | 22% |
| Spain | 19 | 6% |
| Canada | 7 | 2% |
| Chile | 6 | 2% |
| India | 6 | 2% |
| Japan | 5 | 2% |
| United Kingdom | 4 | 1% |
| Argentina | 3 | 1% |
| Mexico | 3 | 1% |
| Other | 23 | 8% |
| Unknown | 156 | 52% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 253 | 85% |
| Scientists | 27 | 9% |
| Practitioners (doctors, other healthcare professionals) | 12 | 4% |
| Science communicators (journalists, bloggers, editors) | 7 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 239 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 239 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 37 | 15% |
| Student > Master | 31 | 13% |
| Student > Ph. D. Student | 25 | 10% |
| Student > Bachelor | 19 | 8% |
| Student > Doctoral Student | 11 | 5% |
| Other | 32 | 13% |
| Unknown | 84 | 35% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 35 | 15% |
| Biochemistry, Genetics and Molecular Biology | 31 | 13% |
| Immunology and Microbiology | 24 | 10% |
| Agricultural and Biological Sciences | 17 | 7% |
| Chemistry | 7 | 3% |
| Other | 38 | 16% |
| Unknown | 87 | 36% |