| Title |
Patterns of change over time and history of the inflammatory potential of diet and risk of breast cancer among postmenopausal women
|
|---|---|
| Published in |
Breast Cancer Research and Treatment, July 2016
|
| DOI | 10.1007/s10549-016-3925-6 |
| Pubmed ID | |
| Authors |
Fred K. Tabung, Susan E. Steck, Angela D. Liese, Jiajia Zhang, Yunsheng Ma, Karen C. Johnson, Dorothy S. Lane, Lihong Qi, Linda Snetselaar, Mara Z. Vitolins, Judith K. Ockene, James R. Hebert |
| Abstract |
We utilized the dietary inflammatory index (DII) to investigate associations between patterns of change in, and history of the inflammatory potential of diet and risk of breast cancer in the Women's Health Initiative (WHI). We included 70,998 postmenopausal women aged 50-79 years recruited from 1993 to 1998 into the WHI Observational Study and Dietary Modification trial control group and followed through August 29, 2014. We utilized data from food frequency questionnaires administered at baseline and Year 3, to calculate average DII scores, patterns of change in DII, and used these measures in multivariable-adjusted Cox regression models to estimate hazards ratios (HR) and 95 % confidence intervals (CI) for incident invasive breast cancer and its subtypes. After 1,093,947 person-years of follow-up, 3471 cases of invasive breast cancer were identified. There was no substantial association between average DII scores or patterns of change in DII and risk of overall invasive breast cancer (HR, 1.03; 95 % CI, 0.90, 1.17; P-trend = 0.79; comparing extreme average DII quintiles). However, there was a significant nonlinear association between average DII scores and the ER-, PR-, HER2+, subtype (HR, 2.37; 95 % CI, 1.08, 5.20; P-trend = 0.18; comparing extreme quintiles). For patterns of change in DII, the age-adjusted association with ER-, PR-, HER2+ subtype comparing women in the proinflammatory stable to those in the anti-inflammatory stable categories (HR, 1.82; 95 % CI, 1.06, 3.13) persisted in the multivariable-adjusted model but was less precise (HR, 1.85; 95 % CI, 0.96, 3.55; P = 0.06). Dietary inflammatory potential may differentially influence the development of specific breast cancer phenotypes. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 54 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 54 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 10 | 19% |
| Student > Ph. D. Student | 8 | 15% |
| Student > Bachelor | 5 | 9% |
| Professor | 4 | 7% |
| Researcher | 3 | 6% |
| Other | 8 | 15% |
| Unknown | 16 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 14 | 26% |
| Nursing and Health Professions | 8 | 15% |
| Agricultural and Biological Sciences | 4 | 7% |
| Chemistry | 2 | 4% |
| Business, Management and Accounting | 1 | 2% |
| Other | 7 | 13% |
| Unknown | 18 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 August 2016.
All research outputs
#18,466,751
of 22,881,964 outputs
Outputs from Breast Cancer Research and Treatment
#3,721
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Outputs of similar age
#282,453
of 365,576 outputs
Outputs of similar age from Breast Cancer Research and Treatment
#77
of 111 outputs
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