↓ Skip to main content

Structural Network Disorganization in Subjects at Clinical High Risk for Psychosis

Overview of attention for article published in Schizophrenia Bulletin, August 2016
Altmetric Badge

About this Attention Score

  • Average Attention Score compared to outputs of the same age
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

twitter
3 X users

Citations

dimensions_citation
51 Dimensions

Readers on

mendeley
101 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Structural Network Disorganization in Subjects at Clinical High Risk for Psychosis
Published in
Schizophrenia Bulletin, August 2016
DOI 10.1093/schbul/sbw110
Pubmed ID
Authors

André Schmidt, Nicolas A. Crossley, Fabienne Harrisberger, Renata Smieskova, Claudia Lenz, Anita Riecher-Rössler, Undine E. Lang, Philip McGuire, Paolo Fusar-Poli, Stefan Borgwardt

Abstract

Previous network studies in chronic schizophrenia patients revealed impaired structural organization of the brain's rich-club members, a set of highly interconnected hub regions that play an important integrative role for global brain communication. Moreover, impaired rich-club connectivity has also been found in unaffected siblings of schizophrenia patients, suggesting that abnormal rich-club connectivity is related to familiar, possibly reflecting genetic, vulnerability for schizophrenia. However, no study has yet investigated whether structural rich-club organization is also impaired in individuals with a clinical risk syndrome for psychosis. Diffusion tensor imaging and probabilistic tractography was used to construct structural whole-brain networks in 24 healthy controls and 24 subjects with an at-risk mental state (ARMS). Graph theory was applied to quantify the structural rich-club organization and global network properties. ARMS subjects revealed a significantly altered structural rich-club organization compared with the control group. The disruption of rich-club organization was associated with the severity of negative psychotic symptoms and led to an elevated level of modularity in ARMS subjects. This study shows that abnormal structural rich-club organization is already evident in clinical high-risk subjects for psychosis and further demonstrates the impact of rich-club disorganization on global network communication. Together with previous evidence in chronic schizophrenia patients and unaffected siblings, our findings suggest that abnormal structural rich-club organization may reflect an endophenotypic marker of psychosis.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 101 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 <1%
Unknown 100 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 20 20%
Researcher 18 18%
Student > Master 13 13%
Student > Doctoral Student 10 10%
Professor 5 5%
Other 17 17%
Unknown 18 18%
Readers by discipline Count As %
Neuroscience 22 22%
Psychology 20 20%
Medicine and Dentistry 17 17%
Engineering 3 3%
Nursing and Health Professions 2 2%
Other 5 5%
Unknown 32 32%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 June 2017.
All research outputs
#14,479,715
of 23,205,257 outputs
Outputs from Schizophrenia Bulletin
#2,187
of 3,059 outputs
Outputs of similar age
#217,299
of 367,735 outputs
Outputs of similar age from Schizophrenia Bulletin
#29
of 48 outputs
Altmetric has tracked 23,205,257 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,059 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.2. This one is in the 25th percentile – i.e., 25% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 367,735 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 48 others from the same source and published within six weeks on either side of this one. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.