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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Effective treatment of spasticity using dronabinol in pediatric palliative care
|
|---|---|
| Published in |
European Journal of Paediatric Neurology, July 2016
|
| DOI | 10.1016/j.ejpn.2016.07.021 |
| Pubmed ID | |
| Authors |
Michaela Kuhlen, Jessica I. Hoell, Gabriele Gagnon, Stefan Balzer, Prasad T. Oommen, Arndt Borkhardt, Gisela Janßen |
| Abstract |
Cannabis extracts have a wide therapeutic potential but in many countries they have not been approved for treatment in children so far. We conducted an open, uncontrolled, retrospective study on the administration of dronabinol to determine the value, efficacy, and safety of cannabis-based medicines in the treatment of refractory spasticity in pediatric palliative care. Sixteen children, adolescents and young adults having complex neurological conditions with spasticity (aged 1.3-26.6 years, median 12.7 years) were treated with dronabinol by our specialized pediatric palliative care team between 01.12.2010 and 30.04.2015 in a home-care setting. Therapeutic efficacy and side effects were closely monitored. Drops of the 2.5% oily tetrahydrocannabinol solution (dronabinol) were administered. A promising therapeutic effect was seen, mostly due to abolishment or marked improvement of severe, treatment resistant spasticity (n = 12). In two cases the effect could not be determined, two patients did not benefit. The median duration of treatment was 181 days (range 23-1429 days). Dosages to obtain a therapeutic effect varied from 0.08 to 1.0 mg/kg/d with a median of 0.33 mg/kg/d in patients with a documented therapeutic effect. When administered as an escalating dosage scheme, side effects were rare and only consisted in vomiting and restlessness (one patient each). No serious and enduring side effects occurred even in young children and/or over a longer period of time. In the majority of pediatric palliative patients the treatment with dronabinol showed promising effects in treatment resistant spasticity. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 50% |
| Unknown | 2 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 75% |
| Science communicators (journalists, bloggers, editors) | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 132 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 132 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 16 | 12% |
| Other | 12 | 9% |
| Student > Master | 12 | 9% |
| Student > Bachelor | 12 | 9% |
| Student > Ph. D. Student | 10 | 8% |
| Other | 27 | 20% |
| Unknown | 43 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 41 | 31% |
| Nursing and Health Professions | 10 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 9 | 7% |
| Social Sciences | 5 | 4% |
| Neuroscience | 4 | 3% |
| Other | 15 | 11% |
| Unknown | 48 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 October 2019.
All research outputs
#4,262,161
of 25,374,917 outputs
Outputs from European Journal of Paediatric Neurology
#113
of 1,112 outputs
Outputs of similar age
#72,824
of 380,550 outputs
Outputs of similar age from European Journal of Paediatric Neurology
#6
of 45 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,112 research outputs from this source. They receive a mean Attention Score of 3.8. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 380,550 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 45 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.