| Title |
Thyroid autoimmunity may represent a predisposition for the development of fibromyalgia?
|
|---|---|
| Published in |
Rheumatology International, November 2010
|
| DOI | 10.1007/s00296-010-1620-1 |
| Pubmed ID | |
| Authors |
L. Bazzichi, A. Rossi, C. Zirafa, F. Monzani, S. Tognini, A. Dardano, F. Santini, M. Tonacchera, M. De Servi, C. Giacomelli, F. De Feo, M. Doveri, G. Massimetti, S. Bombardieri |
| Abstract |
In our previous study, we observed that the presence of autoimmune thyroid disease worsens fibromyalgia (FM) symptoms. The aims of this study are to evaluate whether there is a predisposition for the development of FM in patients with Hashimoto's thyroiditis (HT) with or without subclinical hypothyroidism (SCH) and in patients with SCH alone and what is the weight of antithyroid antibody positivity and SCH on FM comorbidity. Fifty-two patients, 39 affected by HT with or without SCH and 13 by SCH, were matched with 37 patients affected by FM and 25 healthy subjects. Blood samples were collected from all study subjects for the determination of serum TSH, free triiodothyronine, free thyroxine, antithyroperoxidase antibody (TPOAb), antithyroglobulin antibody (TgAb) and non-organ-specific autoantibodies. Clinical assessment of patients and controls included the "Fibromyalgia Impact Questionnaire" (FIQ), while pain severity was evaluated using a visual analogue scale (VAS). Patients and controls were also characterized by the presence of diffuse pain, fatigue, paresthesiae, muscle spasms, non-restful sleep, tension headache and presence of mood disorders. FM comorbidity resulted in twelve HT subjects (31%) and none in SCH patient. In particular, FM comorbidity in HT patients without SCH was 33.3% and in HT patients with SCH was 28.5%. Based on our data, we speculate that maybe there is more than a hypothesis regarding the cause-effect relation between thyroid autoimmunity and the presence of FM, thus suggesting a hypothetical role of thyroid autoimmunity in FM pathogenesis. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 80 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 2 | 3% |
| Australia | 1 | 1% |
| United Kingdom | 1 | 1% |
| Unknown | 76 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 17 | 21% |
| Student > Bachelor | 11 | 14% |
| Student > Doctoral Student | 10 | 13% |
| Researcher | 9 | 11% |
| Professor | 5 | 6% |
| Other | 14 | 18% |
| Unknown | 14 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 41 | 51% |
| Nursing and Health Professions | 8 | 10% |
| Social Sciences | 4 | 5% |
| Agricultural and Biological Sciences | 3 | 4% |
| Psychology | 3 | 4% |
| Other | 7 | 9% |
| Unknown | 14 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 February 2018.
All research outputs
#16,919,456
of 25,654,806 outputs
Outputs from Rheumatology International
#1,737
of 2,498 outputs
Outputs of similar age
#150,368
of 189,582 outputs
Outputs of similar age from Rheumatology International
#12
of 17 outputs
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