Title |
Optimization of Response Classification Criteria for Patients with Malignant Pleural Mesothelioma
|
---|---|
Published in |
Journal of Thoracic Oncology, November 2012
|
DOI | 10.1097/jto.0b013e318269fe21 |
Pubmed ID | |
Authors |
Zacariah E. Labby, Samuel G. Armato, Hedy L. Kindler, James J. Dignam, Arman Hasani, Anna K. Nowak |
Abstract |
Response-assessment metrics play an important role in clinical trials and routine patient management. For patients with malignant pleural mesothelioma (MPM), the standard for response assessment is image-based measurements of tumor thickness made according to the modified RECIST (Response Evaluation Criteria in Solid Tumors) protocol. To classify tumor response, changes in tumor thickness are compared with the standard RECIST -30% and +20% cutoffs for partial response (PR) and progressive disease (PD), respectively, which are not specific to MPM. The purpose of this work is to optimize the correlation between tumor response and patient survival by assessing the validity of existing response criteria in MPM and proposing alternative criteria. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 3 | 75% |
Unknown | 1 | 25% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 75% |
Practitioners (doctors, other healthcare professionals) | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Germany | 1 | 4% |
Unknown | 24 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 5 | 20% |
Other | 3 | 12% |
Student > Doctoral Student | 3 | 12% |
Researcher | 3 | 12% |
Professor > Associate Professor | 2 | 8% |
Other | 4 | 16% |
Unknown | 5 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 13 | 52% |
Agricultural and Biological Sciences | 2 | 8% |
Unspecified | 1 | 4% |
Nursing and Health Professions | 1 | 4% |
Unknown | 8 | 32% |