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Altered Brain Microstate Dynamics in Adolescents with Narcolepsy

Overview of attention for article published in Frontiers in Human Neuroscience, August 2016
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Title
Altered Brain Microstate Dynamics in Adolescents with Narcolepsy
Published in
Frontiers in Human Neuroscience, August 2016
DOI 10.3389/fnhum.2016.00369
Pubmed ID
Authors

Natasha M. Drissi, Attila Szakács, Suzanne T. Witt, Anna Wretman, Martin Ulander, Henriettae Ståhlbrandt, Niklas Darin, Tove Hallböök, Anne-Marie Landtblom, Maria Engström

Abstract

Narcolepsy is a chronic sleep disorder caused by a loss of hypocretin-1 producing neurons in the hypothalamus. Previous neuroimaging studies have investigated brain function in narcolepsy during rest using positron emission tomography (PET) and single photon emission computed tomography (SPECT). In addition to hypothalamic and thalamic dysfunction they showed aberrant prefrontal perfusion and glucose metabolism in narcolepsy. Given these findings in brain structure and metabolism in narcolepsy, we anticipated that changes in functional magnetic resonance imaging (fMRI) resting state network (RSN) dynamics might also be apparent in patients with narcolepsy. The objective of this study was to investigate and describe brain microstate activity in adolescents with narcolepsy and correlate these to RSNs using simultaneous fMRI and electroencephalography (EEG). Sixteen adolescents (ages 13-20) with a confirmed diagnosis of narcolepsy were recruited and compared to age-matched healthy controls. Simultaneous EEG and fMRI data were collected during 10 min of wakeful rest. EEG data were analyzed for microstates, which are discrete epochs of stable global brain states obtained from topographical EEG analysis. Functional MRI data were analyzed for RSNs. Data showed that narcolepsy patients were less likely than controls to spend time in a microstate which we found to be related to the default mode network and may suggest a disruption of this network that is disease specific. We concluded that adolescents with narcolepsy have altered resting state brain dynamics.

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Mendeley readers

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Geographical breakdown

Country Count As %
Hungary 1 1%
Unknown 98 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 18 18%
Student > Master 15 15%
Researcher 10 10%
Professor > Associate Professor 7 7%
Student > Bachelor 6 6%
Other 15 15%
Unknown 28 28%
Readers by discipline Count As %
Neuroscience 26 26%
Medicine and Dentistry 17 17%
Psychology 7 7%
Engineering 6 6%
Physics and Astronomy 2 2%
Other 7 7%
Unknown 34 34%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 August 2016.
All research outputs
#18,466,751
of 22,881,964 outputs
Outputs from Frontiers in Human Neuroscience
#6,078
of 7,170 outputs
Outputs of similar age
#284,116
of 367,231 outputs
Outputs of similar age from Frontiers in Human Neuroscience
#150
of 168 outputs
Altmetric has tracked 22,881,964 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
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