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Innate Immunity and Asthma Risk in Amish and Hutterite Farm Children

Overview of attention for article published in New England Journal of Medicine, August 2016
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  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Citations

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749 Dimensions

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769 Mendeley
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1 CiteULike
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Title
Innate Immunity and Asthma Risk in Amish and Hutterite Farm Children
Published in
New England Journal of Medicine, August 2016
DOI 10.1056/nejmoa1508749
Pubmed ID
Authors

Michelle M Stein, Cara L Hrusch, Justyna Gozdz, Catherine Igartua, Vadim Pivniouk, Sean E Murray, Julie G Ledford, Mauricius Marques Dos Santos, Rebecca L Anderson, Nervana Metwali, Julia W Neilson, Raina M Maier, Jack A Gilbert, Mark Holbreich, Peter S Thorne, Fernando D Martinez, Erika von Mutius, Donata Vercelli, Carole Ober, Anne I Sperling

Abstract

Background The Amish and Hutterites are U.S. agricultural populations whose lifestyles are remarkably similar in many respects but whose farming practices, in particular, are distinct; the former follow traditional farming practices whereas the latter use industrialized farming practices. The populations also show striking disparities in the prevalence of asthma, and little is known about the immune responses underlying these disparities. Methods We studied environmental exposures, genetic ancestry, and immune profiles among 60 Amish and Hutterite children, measuring levels of allergens and endotoxins and assessing the microbiome composition of indoor dust samples. Whole blood was collected to measure serum IgE levels, cytokine responses, and gene expression, and peripheral-blood leukocytes were phenotyped with flow cytometry. The effects of dust extracts obtained from Amish and Hutterite homes on immune and airway responses were assessed in a murine model of experimental allergic asthma. Results Despite the similar genetic ancestries and lifestyles of Amish and Hutterite children, the prevalence of asthma and allergic sensitization was 4 and 6 times as low in the Amish, whereas median endotoxin levels in Amish house dust was 6.8 times as high. Differences in microbial composition were also observed in dust samples from Amish and Hutterite homes. Profound differences in the proportions, phenotypes, and functions of innate immune cells were also found between the two groups of children. In a mouse model of experimental allergic asthma, the intranasal instillation of dust extracts from Amish but not Hutterite homes significantly inhibited airway hyperreactivity and eosinophilia. These protective effects were abrogated in mice that were deficient in MyD88 and Trif, molecules that are critical in innate immune signaling. Conclusions The results of our studies in humans and mice indicate that the Amish environment provides protection against asthma by engaging and shaping the innate immune response. (Funded by the National Institutes of Health and others.).

X Demographics

X Demographics

The data shown below were collected from the profiles of 449 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 769 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 5 <1%
Germany 2 <1%
Italy 2 <1%
Australia 2 <1%
United Kingdom 2 <1%
Spain 2 <1%
Tunisia 1 <1%
Denmark 1 <1%
France 1 <1%
Other 2 <1%
Unknown 749 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 131 17%
Researcher 116 15%
Student > Master 79 10%
Student > Bachelor 76 10%
Student > Doctoral Student 45 6%
Other 154 20%
Unknown 168 22%
Readers by discipline Count As %
Medicine and Dentistry 162 21%
Agricultural and Biological Sciences 96 12%
Immunology and Microbiology 93 12%
Biochemistry, Genetics and Molecular Biology 79 10%
Environmental Science 26 3%
Other 122 16%
Unknown 191 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1579. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 March 2024.
All research outputs
#7,171
of 25,563,770 outputs
Outputs from New England Journal of Medicine
#379
of 32,566 outputs
Outputs of similar age
#80
of 382,449 outputs
Outputs of similar age from New England Journal of Medicine
#4
of 319 outputs
Altmetric has tracked 25,563,770 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 32,566 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 122.5. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 382,449 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 319 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.