| Title |
Sevoflurane Combined with ATP Activates Caspase-1 and Triggers Caspase-1-Dependent Pyroptosis in Murine J774 Macrophages
|
|---|---|
| Published in |
Inflammation, September 2012
|
| DOI | 10.1007/s10753-012-9550-6 |
| Pubmed ID | |
| Authors |
Yue Jin, Hui Li, Guohao Xie, Shuzhen Chen, Shuijin Wu, Xiangming Fang |
| Abstract |
Sevoflurane is one of the most commonly used volatile anesthetics. Recent studies have shown that sevoflurane plays an important role in modulation of inflammation and immunity. However, little is known about the related molecular mechanisms. This study was designed to investigate the effects and mechanisms of sevoflurane on inflammatory cell death pyroptosis in the murine macrophage cell line J774 cells. Sevoflurane combined with ATP could increase the level of activated caspase-1, pyroptosis, and reactive oxygen species (ROS). Furthermore, treatment of cells with the caspase-1 inhibitor Ac-YVAD-CMK dramatically decreased the percentage of pyroptosis. In addition, inhibition of ROS with N-acetyl-L-cysteine or diphenyleneiodonium significantly reduced the activated levels of caspase-1. These results demonstrated that sevoflurane combined with ATP could activate caspase-1 and trigger caspase-1-dependent pyroptosis through the modulation of ROS production. |
Mendeley readers
The data shown below were compiled from readership statistics for 14 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 14 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Librarian | 2 | 14% |
| Student > Ph. D. Student | 2 | 14% |
| Student > Bachelor | 2 | 14% |
| Other | 1 | 7% |
| Student > Doctoral Student | 1 | 7% |
| Other | 2 | 14% |
| Unknown | 4 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 5 | 36% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 14% |
| Agricultural and Biological Sciences | 2 | 14% |
| Environmental Science | 1 | 7% |
| Unknown | 4 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 October 2012.
All research outputs
#20,171,868
of 22,684,168 outputs
Outputs from Inflammation
#708
of 1,045 outputs
Outputs of similar age
#152,790
of 171,753 outputs
Outputs of similar age from Inflammation
#11
of 15 outputs
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