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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Specification of tissue-resident macrophages during organogenesis
|
|---|---|
| Published in |
Science, August 2016
|
| DOI | 10.1126/science.aaf4238 |
| Pubmed ID | |
| Authors |
Elvira Mass, Ivan Ballesteros, Matthias Farlik, Florian Halbritter, Patrick Günther, Lucile Crozet, Christian E Jacome-Galarza, Kristian Händler, Johanna Klughammer, Yasuhiro Kobayashi, Elisa Gomez-Perdiguero, Joachim L Schultze, Marc Beyer, Christoph Bock, Frederic Geissmann |
| Abstract |
Tissue-resident macrophages support embryonic development and tissue homeostasis and repair. The mechanisms that control their differentiation remain unclear. We report here that erythro-myeloid progenitors generate pre-macrophages (pMacs) that simultaneously colonize the whole embryo from embryonic day (E)9.5 in a chemokine-receptor dependent manner. The core macrophage program initiated in pMacs is rapidly diversified as expression of transcriptional regulators becomes tissue-specific in early macrophages. This process appears essential for macrophage specification and maintenance, as inactivation of Id3 impairs the development of liver macrophages and results in selective Kupffer cell deficiency in adults. We propose that macrophage differentiation is an integral part of organogenesis as colonization of organ anlagen by pMacs is followed by their specification into tissue macrophages, hereby generating the macrophage diversity observed in postnatal tissues. |
X Demographics
The data shown below were collected from the profiles of 35 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 6 | 17% |
| United Kingdom | 3 | 9% |
| France | 2 | 6% |
| Austria | 2 | 6% |
| Sweden | 1 | 3% |
| Saudi Arabia | 1 | 3% |
| Canada | 1 | 3% |
| Comoros | 1 | 3% |
| Unknown | 18 | 51% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 26 | 74% |
| Scientists | 6 | 17% |
| Science communicators (journalists, bloggers, editors) | 2 | 6% |
| Practitioners (doctors, other healthcare professionals) | 1 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 915 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 3 | <1% |
| United States | 3 | <1% |
| Netherlands | 1 | <1% |
| Austria | 1 | <1% |
| France | 1 | <1% |
| United Kingdom | 1 | <1% |
| Sweden | 1 | <1% |
| Unknown | 904 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 237 | 26% |
| Researcher | 148 | 16% |
| Student > Master | 89 | 10% |
| Student > Bachelor | 81 | 9% |
| Student > Doctoral Student | 47 | 5% |
| Other | 116 | 13% |
| Unknown | 197 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 183 | 20% |
| Immunology and Microbiology | 162 | 18% |
| Agricultural and Biological Sciences | 144 | 16% |
| Medicine and Dentistry | 90 | 10% |
| Neuroscience | 62 | 7% |
| Other | 63 | 7% |
| Unknown | 211 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 77. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 February 2024.
All research outputs
#554,032
of 25,374,647 outputs
Outputs from Science
#12,929
of 82,915 outputs
Outputs of similar age
#11,282
of 381,909 outputs
Outputs of similar age from Science
#219
of 1,043 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 82,915 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 65.7. This one has done well, scoring higher than 84% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 381,909 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 1,043 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 79% of its contemporaries.