| Title |
Beneficial effect of repetitive transcranial magnetic stimulation combined with cognitive training for the treatment of Alzheimer’s disease: a proof of concept study
|
|---|---|
| Published in |
Journal of Neural Transmission, January 2011
|
| DOI | 10.1007/s00702-010-0578-1 |
| Pubmed ID | |
| Authors |
Jonathan Bentwich, Evgenia Dobronevsky, Sergio Aichenbaum, Ran Shorer, Ruth Peretz, Michael Khaigrekht, Revital Gandelman Marton, Jose M. Rabey |
| Abstract |
The current drug treatment for Alzheimer's disease (AD) is only partially and temporary effective. Transcranial magnetic stimulation (TMS) is a non-invasive technique that generates an electric current inducing modulation in cortical excitability. In addition, cognitive training (COG) may improve cognitive functions in AD. Our aim was to treat AD patients combining high-frequency repetitive TMS interlaced with COG (rTMS-COG). Eight patients with probable AD, treated for more than 2 months with cholinesterase inhibitors, were subjected to daily rTMS-COG sessions (5/week) for 6 weeks, followed by maintenance sessions (2/week) for an additional 3 months. Six brain regions, located individually by MRI, were stimulated. COG tasks were developed to fit these regions. Primary objectives were average improvement of Alzheimer Disease Assessment Scale-Cognitive (ADAS-cog) and Clinical Global Impression of Change (CGIC) (after 6 weeks and 4.5 months, compared to baseline). Secondary objectives were average improvement of MMSE, ADAS-ADL, Hamilton Depression Scale (HAMILTON) and Neuropsychiatric Inventory (NPI). One patient abandoned the study after 2 months (severe urinary sepsis). ADAS-cog (average) improved by approximately 4 points after both 6 weeks and 4.5 months of treatment (P < 0.01 and P < 0.05) and CGIC by 1.0 and 1.6 points, respectively. MMSE, ADAS-ADL and HAMILTON improved, but without statistical significance. NPI did not change. No side effects were recorded. In this study, rTMS-COG (provided by Neuronix Ltd., Yokneam, Israel) seems a promising effective and safe modality for AD treatment, possibly as good as cholinesterase inhibitors. A European double blind study is underway. |
Mendeley readers
The data shown below were compiled from readership statistics for 320 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 2 | <1% |
| United States | 2 | <1% |
| Italy | 1 | <1% |
| Netherlands | 1 | <1% |
| United Kingdom | 1 | <1% |
| India | 1 | <1% |
| Mexico | 1 | <1% |
| Canada | 1 | <1% |
| Unknown | 310 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 56 | 18% |
| Student > Ph. D. Student | 46 | 14% |
| Researcher | 44 | 14% |
| Student > Bachelor | 34 | 11% |
| Student > Postgraduate | 16 | 5% |
| Other | 55 | 17% |
| Unknown | 69 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 58 | 18% |
| Neuroscience | 58 | 18% |
| Medicine and Dentistry | 57 | 18% |
| Agricultural and Biological Sciences | 21 | 7% |
| Engineering | 8 | 3% |
| Other | 27 | 8% |
| Unknown | 91 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 25. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 April 2017.
All research outputs
#1,296,721
of 22,684,168 outputs
Outputs from Journal of Neural Transmission
#37
of 1,760 outputs
Outputs of similar age
#7,225
of 182,054 outputs
Outputs of similar age from Journal of Neural Transmission
#3
of 24 outputs
Altmetric has tracked 22,684,168 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,760 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.5. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 182,054 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 24 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 87% of its contemporaries.