| Title |
Clinical review: The liver in sepsis
|
|---|---|
| Published in |
Critical Care, October 2012
|
| DOI | 10.1186/cc11381 |
| Pubmed ID | |
| Authors |
Nicolas Nesseler, Yoann Launey, Caroline Aninat, Fabrice Morel, Yannick Mallédant, Philippe Seguin |
| Abstract |
ABSTRACT: During sepsis, the liver plays a key role. It is implicated in the host response, participating in the clearance of the infectious agents/products. Sepsis also induces liver damage through hemodynamic alterations or through direct or indirect assault on the hepatocytes or through both. Accordingly, liver dysfunction induced by sepsis is recognized as one of the components that contribute to the severity of the disease. Nevertheless, the incidence of liver dysfunction remains imprecise, probably because current diagnostic tools are lacking, notably those that can detect the early liver insult. In this review, we discuss the epidemiology, diagnostic tools, and impact on outcome as well as the pathophysiological aspects, including the cellular events and clinical picture leading to liver dysfunction. Finally, therapeutic considerations with regard to the weakness of the pertinent specific approach are examined. |
X Demographics
The data shown below were collected from the profiles of 11 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 3 | 27% |
| Mexico | 1 | 9% |
| Australia | 1 | 9% |
| Unknown | 6 | 55% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 9 | 82% |
| Practitioners (doctors, other healthcare professionals) | 1 | 9% |
| Scientists | 1 | 9% |
Mendeley readers
The data shown below were compiled from readership statistics for 316 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Italy | 3 | <1% |
| Brazil | 3 | <1% |
| Indonesia | 1 | <1% |
| Austria | 1 | <1% |
| France | 1 | <1% |
| South Africa | 1 | <1% |
| Spain | 1 | <1% |
| Unknown | 305 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 38 | 12% |
| Student > Ph. D. Student | 36 | 11% |
| Student > Doctoral Student | 35 | 11% |
| Student > Postgraduate | 29 | 9% |
| Researcher | 28 | 9% |
| Other | 80 | 25% |
| Unknown | 70 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 146 | 46% |
| Agricultural and Biological Sciences | 21 | 7% |
| Biochemistry, Genetics and Molecular Biology | 20 | 6% |
| Veterinary Science and Veterinary Medicine | 10 | 3% |
| Pharmacology, Toxicology and Pharmaceutical Science | 10 | 3% |
| Other | 34 | 11% |
| Unknown | 75 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 19. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 October 2023.
All research outputs
#1,965,577
of 25,374,917 outputs
Outputs from Critical Care
#1,762
of 6,554 outputs
Outputs of similar age
#13,326
of 202,134 outputs
Outputs of similar age from Critical Care
#5
of 126 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 6,554 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.8. This one has gotten more attention than average, scoring higher than 73% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 202,134 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 126 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.