| Title |
Comparison of the binding characteristics of [18F]THK-523 and other amyloid imaging tracers to Alzheimer’s disease pathology
|
|---|---|
| Published in |
European Journal of Nuclear Medicine and Molecular Imaging, October 2012
|
| DOI | 10.1007/s00259-012-2261-2 |
| Pubmed ID | |
| Authors |
Ryuichi Harada, Nobuyuki Okamura, Shozo Furumoto, Tetsuro Tago, Masahiro Maruyama, Makoto Higuchi, Takeo Yoshikawa, Hiroyuki Arai, Ren Iwata, Yukitsuka Kudo, Kazuhiko Yanai |
| Abstract |
Extensive deposition of senile plaques and neurofibrillary tangles in the brain is a pathological hallmark of Alzheimer's disease (AD). Although several PET imaging agents have been developed for in vivo detection of senile plaques, no PET probe is currently available for selective detection of neurofibrillary tangles in the living human brain. Recently, [(18)F]THK-523 was developed as a potential in vivo imaging probe for tau pathology. The purpose of this study was to compare the binding properties of [(18)F]THK-523 and other amyloid imaging agents, including PiB, BF-227 and FDDNP, to synthetic protein fibrils and human brain tissue. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 76 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 3% |
| France | 2 | 3% |
| Russia | 1 | 1% |
| Unknown | 71 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 22 | 29% |
| Student > Ph. D. Student | 10 | 13% |
| Student > Master | 7 | 9% |
| Professor | 7 | 9% |
| Student > Bachelor | 6 | 8% |
| Other | 13 | 17% |
| Unknown | 11 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 18 | 24% |
| Chemistry | 13 | 17% |
| Neuroscience | 11 | 14% |
| Agricultural and Biological Sciences | 7 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 4% |
| Other | 9 | 12% |
| Unknown | 15 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 April 2024.
All research outputs
#4,900,361
of 23,806,312 outputs
Outputs from European Journal of Nuclear Medicine and Molecular Imaging
#586
of 3,083 outputs
Outputs of similar age
#35,612
of 184,947 outputs
Outputs of similar age from European Journal of Nuclear Medicine and Molecular Imaging
#2
of 20 outputs
Altmetric has tracked 23,806,312 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,083 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.1. This one has done well, scoring higher than 80% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 184,947 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 20 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.