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Clozapine users in Australia: their characteristics and experiences of care based on data from the 2010 National Survey of High Impact Psychosis

Overview of attention for article published in Epidemiology and Psychiatric Sciences, July 2016
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Title
Clozapine users in Australia: their characteristics and experiences of care based on data from the 2010 National Survey of High Impact Psychosis
Published in
Epidemiology and Psychiatric Sciences, July 2016
DOI 10.1017/s2045796016000305
Pubmed ID
Authors

D. J. Siskind, M. Harris, A. Phillipou, V. A. Morgan, A. Waterreus, C. Galletly, V. J. Carr, C. Harvey, D. Castle

Abstract

Clozapine is the most effective medication for treatment refractory schizophrenia. However, descriptions of the mental health and comorbidity profile and care experiences of people on clozapine in routine clinical settings are scarce. Using data from the 2010 Australian Survey of High Impact Psychosis, we aimed to examine the proportion of people using clozapine, and to compare clozapine users with other antipsychotic users on demographic, mental health, adverse drug reaction, polypharmacy and treatment satisfaction variables. Data describing 1049 people with a diagnosis of schizophrenia or schizoaffective disorder, who reported taking any antipsychotic medication in the previous 4 weeks, were drawn from a representative Australian survey of people with psychotic disorders in contact with mental health services in the previous 12 months. We compared participants taking clozapine (n = 257, 22.4%) with those taking other antipsychotic medications, on a range of demographic, clinical and treatment-related indicators. One quarter of participants were on clozapine. Of participants with a chronic course of illness, only one third were on clozapine. After adjusting for diagnosis and illness chronicity, participants taking clozapine had significantly lower odds of current alcohol, cannabis and other drug use despite similar lifetime odds. Metabolic syndrome and diabetes were more common among people taking clozapine; chronic pain was less common. Psychotropic polypharmacy did not differ between groups. Consistent with international evidence of clozapine underutilisation, a large number of participants with chronic illness and high symptom burden were not taking clozapine. The lower probabilities of current substance use and chronic pain among clozapine users warrant further study.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 107 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Chile 1 <1%
Unknown 106 99%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 14 13%
Student > Ph. D. Student 12 11%
Student > Master 11 10%
Researcher 10 9%
Student > Doctoral Student 6 6%
Other 20 19%
Unknown 34 32%
Readers by discipline Count As %
Medicine and Dentistry 21 20%
Psychology 14 13%
Nursing and Health Professions 8 7%
Pharmacology, Toxicology and Pharmaceutical Science 5 5%
Neuroscience 3 3%
Other 15 14%
Unknown 41 38%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 June 2017.
All research outputs
#22,758,309
of 25,373,627 outputs
Outputs from Epidemiology and Psychiatric Sciences
#806
of 901 outputs
Outputs of similar age
#335,127
of 377,580 outputs
Outputs of similar age from Epidemiology and Psychiatric Sciences
#13
of 14 outputs
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So far Altmetric has tracked 901 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 16.7. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.