Title |
Viral fitness: definitions, measurement, and current insights
|
---|---|
Published in |
Current Opinion in Virology, September 2012
|
DOI | 10.1016/j.coviro.2012.07.007 |
Pubmed ID | |
Authors |
Andrew R Wargo, Gael Kurath |
Abstract |
Viral fitness is an active area of research, with recent work involving an expanded number of human, non-human vertebrate, invertebrate, plant, and bacterial viruses. Many publications deal with RNA viruses associated with major disease emergence events, such as HIV-1, influenza virus, and Dengue virus. Study topics include drug resistance, immune escape, viral emergence, host jumps, mutation effects, quasispecies diversity, and mathematical models of viral fitness. Important recent trends include increasing use of in vivo systems to assess vertebrate virus fitness, and a broadening of research beyond replicative fitness to also investigate transmission fitness and epidemiologic fitness. This is essential for a more integrated understanding of overall viral fitness, with implications for disease management in the future. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 2 | 12% |
Italy | 1 | 6% |
Ireland | 1 | 6% |
United States | 1 | 6% |
Canada | 1 | 6% |
Chile | 1 | 6% |
Argentina | 1 | 6% |
Unknown | 9 | 53% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 15 | 88% |
Scientists | 2 | 12% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Portugal | 1 | <1% |
Germany | 1 | <1% |
Chile | 1 | <1% |
France | 1 | <1% |
Norway | 1 | <1% |
Israel | 1 | <1% |
United Kingdom | 1 | <1% |
Saudi Arabia | 1 | <1% |
Spain | 1 | <1% |
Other | 1 | <1% |
Unknown | 263 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 60 | 22% |
Student > Ph. D. Student | 53 | 19% |
Student > Master | 33 | 12% |
Student > Bachelor | 32 | 12% |
Student > Doctoral Student | 17 | 6% |
Other | 42 | 15% |
Unknown | 36 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 92 | 34% |
Biochemistry, Genetics and Molecular Biology | 42 | 15% |
Immunology and Microbiology | 27 | 10% |
Medicine and Dentistry | 20 | 7% |
Veterinary Science and Veterinary Medicine | 14 | 5% |
Other | 27 | 10% |
Unknown | 51 | 19% |