Title |
Factors Associated with Interest in Gene‐Panel Testing and Risk Communication Preferences in Women from BRCA1/2 Negative Families
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Published in |
Journal of Genetic Counseling, August 2016
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DOI | 10.1007/s10897-016-0001-7 |
Pubmed ID | |
Authors |
Kristina G. Flores, Laurie E. Steffen, Christopher J. McLouth, Belinda E. Vicuña, Amanda Gammon, Wendy Kohlmann, Lucretia Vigil, Zoneddy R. Dayao, Melanie E. Royce, Anita Y. Kinney |
Abstract |
Scientific advances have allowed the development of multiplex gene-panels to assess many genes simultaneously in women who have tested negative for BRCA1/2. We examined correlates of interest in testing for genes that confer modest and moderate breast cancer risk and risk communication preferences for women from BRCA negative families. Female first-degree relatives of breast cancer patients who tested negative for BRCA1/2 mutations (N = 149) completed a survey assessing multiplex genetic testing interest and risk communication preferences. Interest in testing was high (70 %) and even higher if results could guide risk-reducing behavior changes such as taking medications (79 %). Participants preferred to receive genomic risk communications from a variety of sources including: primary care physicians (83 %), genetic counselors (78 %), printed materials (71 %) and the web (60 %). Factors that were independently associated with testing interest were: perceived lifetime risk of developing cancer (odds ratio (OR) = 1.67: 95 % confidence interval (CI) 1.06-2.65) and high cancer worry (OR = 3.12: CI 1.28-7.60). Findings suggest that women from BRCA1/2 negative families are a unique population and may be primed for behavior change. Findings also provide guidance for clinicians who can help develop genomic risk communications, promote informed decision making and customize behavioral interventions. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 50% |
Unknown | 2 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 4 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Canada | 1 | 1% |
Unknown | 67 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 15 | 22% |
Student > Ph. D. Student | 8 | 12% |
Student > Master | 7 | 10% |
Student > Postgraduate | 5 | 7% |
Student > Bachelor | 5 | 7% |
Other | 12 | 18% |
Unknown | 16 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 11 | 16% |
Psychology | 6 | 9% |
Biochemistry, Genetics and Molecular Biology | 5 | 7% |
Social Sciences | 5 | 7% |
Agricultural and Biological Sciences | 4 | 6% |
Other | 13 | 19% |
Unknown | 24 | 35% |