| Title |
T-cells in alzheimer’s disease
|
|---|---|
| Published in |
NeuroMolecular Medicine, January 2005
|
| DOI | 10.1385/nmm:7:3:255 |
| Pubmed ID | |
| Authors |
Terrence Town, Jun Tan, Richard A. Flavell, Mike Mullan |
| Abstract |
Alzheimer's disease (AD) is the most common dementing illness and is pathologically characterized by deposition of the 40-42 amino acid peptide, amyloid-beta (Abeta), as senile plaques. It is well documented that brain inflammatory mechanisms mediated by reactive glia are activated in response to Abeta plaques. A number of reports further suggest that T-cells are activated in AD patients, and that these cells exist both in the periphery and as infiltrates in the brain. We explore the potential role of T-cells in the AD process, a controversial area, by reviewing reports that show disturbed activation profiles and/or altered numbers of various subsets of T-cells in the circulation as well as in the AD brain parenchyma and in cerebral amyloid angiopathy. We also discuss the recent Abeta immunotherapy approach vis-à-vis the activated, autoaggressive T-cell infiltrates that contributed to aseptic meningoencephalitis in a small percentage of patients, and present possible alternative approaches that may be both efficacious and safe. Finally, we explore the use of mouse models of AD as a system within which to definitively test the possible contribution of T-cells to AD pathogenesis. |
Mendeley readers
The data shown below were compiled from readership statistics for 130 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 2% |
| United Kingdom | 1 | <1% |
| Spain | 1 | <1% |
| China | 1 | <1% |
| Unknown | 125 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 27 | 21% |
| Researcher | 15 | 12% |
| Student > Master | 15 | 12% |
| Student > Bachelor | 12 | 9% |
| Student > Doctoral Student | 11 | 8% |
| Other | 26 | 20% |
| Unknown | 24 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 24 | 18% |
| Neuroscience | 23 | 18% |
| Biochemistry, Genetics and Molecular Biology | 20 | 15% |
| Medicine and Dentistry | 16 | 12% |
| Immunology and Microbiology | 4 | 3% |
| Other | 14 | 11% |
| Unknown | 29 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 November 2013.
All research outputs
#8,262,107
of 25,374,647 outputs
Outputs from NeuroMolecular Medicine
#191
of 478 outputs
Outputs of similar age
#38,123
of 151,221 outputs
Outputs of similar age from NeuroMolecular Medicine
#3
of 8 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one has received more attention than most of these and is in the 66th percentile.
So far Altmetric has tracked 478 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.5. This one has gotten more attention than average, scoring higher than 59% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 151,221 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 5 of them.