| Title |
Identification of PADI2 as a potential breast cancer biomarker and therapeutic target
|
|---|---|
| Published in |
BMC Cancer, October 2012
|
| DOI | 10.1186/1471-2407-12-500 |
| Pubmed ID | |
| Authors |
John L McElwee, Sunish Mohanan, Obi L Griffith, Heike C Breuer, Lynne J Anguish, Brian D Cherrington, Ashley M Palmer, Louise R Howe, Venkataraman Subramanian, Corey P Causey, Paul R Thompson, Joe W Gray, Scott A Coonrod |
| Abstract |
We have recently reported that the expression of peptidylarginine deiminase 2 (PADI2) is regulated by EGF in mammary cancer cells and appears to play a role in the proliferation of normal mammary epithelium; however, the role of PADI2 in the pathogenesis of human breast cancer has yet to be investigated. Thus, the goals of this study were to examine whether PADI2 plays a role in mammary tumor progression, and whether the inhibition of PADI activity has anti-tumor effects. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 74 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 3% |
| United Kingdom | 1 | 1% |
| Canada | 1 | 1% |
| Unknown | 70 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 20 | 27% |
| Researcher | 12 | 16% |
| Student > Master | 9 | 12% |
| Student > Bachelor | 5 | 7% |
| Student > Doctoral Student | 4 | 5% |
| Other | 9 | 12% |
| Unknown | 15 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 20 | 27% |
| Biochemistry, Genetics and Molecular Biology | 16 | 22% |
| Medicine and Dentistry | 8 | 11% |
| Chemistry | 6 | 8% |
| Immunology and Microbiology | 3 | 4% |
| Other | 4 | 5% |
| Unknown | 17 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 November 2012.
All research outputs
#17,670,096
of 22,684,168 outputs
Outputs from BMC Cancer
#4,956
of 8,249 outputs
Outputs of similar age
#134,529
of 183,634 outputs
Outputs of similar age from BMC Cancer
#71
of 110 outputs
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So far Altmetric has tracked 8,249 research outputs from this source. They receive a mean Attention Score of 4.3. This one is in the 34th percentile – i.e., 34% of its peers scored the same or lower than it.
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We're also able to compare this research output to 110 others from the same source and published within six weeks on either side of this one. This one is in the 33rd percentile – i.e., 33% of its contemporaries scored the same or lower than it.