| Title |
Tell Me a Tale of TALEs
|
|---|---|
| Published in |
Molecular Biotechnology, November 2012
|
| DOI | 10.1007/s12033-012-9619-3 |
| Pubmed ID | |
| Authors |
Alejandra Muñoz Bodnar, Adriana Bernal, Boris Szurek, Camilo E. López |
| Abstract |
Pathogenic bacteria of the Xanthomonas and Ralstonia genus have developed resourceful strategies creating a favorable environment to multiply and colonize their host plants. One of these strategies involves the secretion and translocation of several families of effector proteins into the host cell. The transcription activator-like effector (TALE) family forms a subset of proteins involved in the direct modulation of host gene expression. TALEs include a number of tandem 34-amino acid repeats in their central part, where specific residues variable in two adjacent positions determine DNA-binding in the host genome. The specificity of this binding and its predictable nature make TALEs a revolutionary tool for gene editing, functional analysis, modification of target gene expression, and directed mutagenesis. Several examples have been reported in higher organisms as diverse as plants, Drosophila, zebrafish, mouse, and even human cells. Here, we summarize the functions of TALEs in their natural context and the biotechnological perspectives of their use. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Scientists | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 111 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 2 | 2% |
| France | 1 | <1% |
| Portugal | 1 | <1% |
| Paraguay | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 105 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 23 | 21% |
| Student > Ph. D. Student | 22 | 20% |
| Student > Bachelor | 14 | 13% |
| Student > Master | 12 | 11% |
| Student > Doctoral Student | 6 | 5% |
| Other | 20 | 18% |
| Unknown | 14 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 74 | 67% |
| Biochemistry, Genetics and Molecular Biology | 13 | 12% |
| Medicine and Dentistry | 2 | 2% |
| Arts and Humanities | 1 | <1% |
| Chemical Engineering | 1 | <1% |
| Other | 4 | 4% |
| Unknown | 16 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 December 2012.
All research outputs
#14,154,868
of 22,684,168 outputs
Outputs from Molecular Biotechnology
#600
of 953 outputs
Outputs of similar age
#106,792
of 184,149 outputs
Outputs of similar age from Molecular Biotechnology
#8
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