| Title |
Hormone receptor status of contralateral breast cancers: analysis of data from the US SEER population-based registries
|
|---|---|
| Published in |
Breast Cancer, August 2016
|
| DOI | 10.1007/s12282-016-0716-1 |
| Pubmed ID | |
| Authors |
Roman Mezencev, Marián Švajdler |
| Abstract |
Women diagnosed with breast cancer display higher propensity to develop second primary cancer in the contralateral breast (CBC). Identification of patients with increased risk of CBC and understanding relationships between hormone receptor (HR) statuses of the first and second breast cancers is desirable for endocrine-based prevention strategies. Using 1992-2012 data from 13 SEER registries, the risk of developing CBC was determined as ratio of observed and expected second breast cancers (SIR). Association between HR statuses was examined by exploratory data analysis and multivariable logistic regression. Women with ER-positive and ER-negative breast cancers have increased risk of developing CBC with SIR values 2.09 (CI 95 = 1.97-2.21) and 2.40 (CI 95 = 2.18-2.63), respectively. ER statuses of the CBC are moderately positively associated. In metachronous CBC, most cases with ER-positive first cancers had ER-positive second breast cancers (81.6 %; CI 95 = 80.2-82.9 %); however, considerable proportion of cases with ER-negative first cancers had ER-positive second cancers (48.8 %; CI 95 = 46.2-51.4 %). Some women with ER-negative breast cancers may benefit from endocrine-based prevention of ER-positive CBC. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 8 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 2 | 25% |
| Librarian | 1 | 13% |
| Student > Doctoral Student | 1 | 13% |
| Other | 1 | 13% |
| Student > Ph. D. Student | 1 | 13% |
| Other | 1 | 13% |
| Unknown | 1 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 2 | 25% |
| Agricultural and Biological Sciences | 2 | 25% |
| Veterinary Science and Veterinary Medicine | 1 | 13% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 13% |
| Unknown | 2 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 August 2016.
All research outputs
#21,476,880
of 23,975,976 outputs
Outputs from Breast Cancer
#458
of 614 outputs
Outputs of similar age
#327,949
of 370,166 outputs
Outputs of similar age from Breast Cancer
#5
of 14 outputs
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