| Title |
Severe somatoform and dysautonomic syndromes after HPV vaccination: case series and review of literature
|
|---|---|
| Published in |
Immunologic Research, August 2016
|
| DOI | 10.1007/s12026-016-8820-z |
| Pubmed ID | |
| Authors |
Beniamino Palmieri, Dimitri Poddighe, Maria Vadalà, Carmen Laurino, Carla Carnovale, Emilio Clementi |
| Abstract |
Human papilloma virus (HPV) is recognized as a major cause for cervical cancer among women worldwide. Two HPV vaccines are currently available: Gardasil(®) and Cervarix(®). Both vaccines enclose viral antigenic proteins, but differ as to the biological systems of culture and the adjuvant components. Recently, a collection of symptoms, indicating nervous system dysfunction, has been described after HPV vaccination. We retrospectively described a case series including 18 girls (aged 12-24 years) referred to our "Second Opinion Medical Network" for the evaluation of "neuropathy with autonomic dysfunction" after HPV vaccination. All girls complained of long-lasting and invalidating somatoform symptoms (including asthenia, headache, cognitive dysfunctions, myalgia, sinus tachycardia and skin rashes) that have developed 1-5 days (n = 11), 5-15 days (n = 5) and 15-20 days (n = 2) after the vaccination. These cases can be included in the recently described immune dysfunction named autoimmune/inflammatory syndrome induced by adjuvants (ASIA). HPV vaccine, through its adjuvant component, is speculated to induce an abnormal activation of the immune system, involving glia cells in the nervous system too. Further researches should aim at defining the pathological and clinical aspects of these post-vaccination diseases and identifying a genetic background predisposing to these adverse reactions. |
X Demographics
The data shown below were collected from the profiles of 453 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 64 | 14% |
| Brazil | 24 | 5% |
| Japan | 21 | 5% |
| Canada | 10 | 2% |
| United Kingdom | 7 | 2% |
| Italy | 3 | <1% |
| France | 3 | <1% |
| Ireland | 3 | <1% |
| Netherlands | 3 | <1% |
| Other | 30 | 7% |
| Unknown | 285 | 63% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 422 | 93% |
| Practitioners (doctors, other healthcare professionals) | 18 | 4% |
| Scientists | 9 | 2% |
| Science communicators (journalists, bloggers, editors) | 3 | <1% |
| Unknown | 1 | <1% |
Mendeley readers
The data shown below were compiled from readership statistics for 121 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| Unknown | 120 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Other | 14 | 12% |
| Student > Bachelor | 14 | 12% |
| Student > Master | 13 | 11% |
| Researcher | 11 | 9% |
| Student > Doctoral Student | 10 | 8% |
| Other | 26 | 21% |
| Unknown | 33 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 38 | 31% |
| Nursing and Health Professions | 9 | 7% |
| Biochemistry, Genetics and Molecular Biology | 9 | 7% |
| Agricultural and Biological Sciences | 3 | 2% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 2% |
| Other | 12 | 10% |
| Unknown | 47 | 39% |
Attention Score in Context
This research output has an Altmetric Attention Score of 372. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 April 2024.
All research outputs
#86,176
of 25,773,273 outputs
Outputs from Immunologic Research
#7
of 953 outputs
Outputs of similar age
#1,809
of 377,606 outputs
Outputs of similar age from Immunologic Research
#1
of 41 outputs
Altmetric has tracked 25,773,273 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 953 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.0. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 377,606 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 41 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.