| Title |
Telomeres and telomerase in head and neck squamous cell carcinoma: from pathogenesis to clinical implications
|
|---|---|
| Published in |
Cancer and Metastasis Reviews, August 2016
|
| DOI | 10.1007/s10555-016-9633-1 |
| Pubmed ID | |
| Authors |
Paolo Boscolo-Rizzo, Maria Cristina Da Mosto, Enrica Rampazzo, Silvia Giunco, Annarosa Del Mistro, Anna Menegaldo, Lorena Baboci, Monica Mantovani, Giancarlo Tirelli, Anita De Rossi |
| Abstract |
Strongly associated with tobacco use, heavy alcohol consumption, and with high-risk human papillomavirus (HPV) infection, head and neck squamous cell carcinoma (HNSCC) is a frequently lethal, heterogeneous disease whose pathogenesis is a multistep and multifactorial process involving genetic and epigenetic events. The majority of HNSCC patients present with locoregional advanced stage disease and are treated with combined modality strategies that can markedly impair quality of life and elicit unpredictable results. A large fraction of those who undergo locoregional treatment and achieve a complete response later develop locoregional recurrences or second field tumors. Biomarkers that are thus able to stratify risk and enable clinicians to tailor treatment plans and to personalize post-therapeutic surveillance strategies are highly desirable. To date, only HPV status is considered a reliable independent predictor of treatment response and survival in patients with HNSCC arising from the oropharyngeal site. Recent studies suggest that telomere attrition, which may be an early event in human carcinogenesis, and telomerase activation, which is detected in up to 90 % of malignancies, could be potential markers of cancer risk and disease outcome. This review examines the current state of knowledge on and discusses the implications linked to telomere dysfunction and telomerase activation in the development and clinical outcome of HNSCC. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 33% |
| France | 1 | 33% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 110 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 110 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 21 | 19% |
| Student > Ph. D. Student | 13 | 12% |
| Student > Postgraduate | 10 | 9% |
| Researcher | 9 | 8% |
| Student > Master | 9 | 8% |
| Other | 24 | 22% |
| Unknown | 24 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 50 | 45% |
| Biochemistry, Genetics and Molecular Biology | 15 | 14% |
| Agricultural and Biological Sciences | 5 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 2% |
| Arts and Humanities | 2 | 2% |
| Other | 4 | 4% |
| Unknown | 32 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 January 2017.
All research outputs
#14,427,926
of 23,577,654 outputs
Outputs from Cancer and Metastasis Reviews
#584
of 829 outputs
Outputs of similar age
#211,051
of 366,607 outputs
Outputs of similar age from Cancer and Metastasis Reviews
#5
of 5 outputs
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