| Title |
In vivo study of hepatitis B vaccine effects on inflammation and metabolism gene expression
|
|---|---|
| Published in |
Molecular Biology Reports, June 2011
|
| DOI | 10.1007/s11033-011-1090-x |
| Pubmed ID | |
| Authors |
Heyam Hamza, Jianhua Cao, Xinyun Li, Shuhong Zhao |
| Abstract |
Pharmaceutical companies usually perform safety testing of vaccines, but all requirements of the World Health Organization and drug pharmacopoeias depend on general toxicity testing, and the gene expression study of hepatitis B vaccine is not done routinely to test vaccine quality. In this study, we applied a new technique of gene expression analysis to detect the inflammation and metabolism genes that might be affected by hepatitis B vaccine in mouse liver. Mice were used and divided into three groups: the first and second groups were treated with one or two human doses of vaccine, respectively, and the third group was used as a control. A microarray test showed that expression of 144 genes in the liver was significantly changed after 1 day of vaccination. Seven of these genes, which were related to inflammation and metabolism, were chosen and confirmed by quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR) at 1, 4 and 7 days. The expression level of these genes can be considered as a biomarker for the effects of the vaccine. |
X Demographics
The data shown below were collected from the profiles of 33 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 15% |
| Japan | 2 | 6% |
| Austria | 1 | 3% |
| Congo | 1 | 3% |
| Georgia | 1 | 3% |
| Norway | 1 | 3% |
| Taiwan | 1 | 3% |
| Unknown | 21 | 64% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 29 | 88% |
| Practitioners (doctors, other healthcare professionals) | 2 | 6% |
| Science communicators (journalists, bloggers, editors) | 1 | 3% |
| Unknown | 1 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 12 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 12 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 4 | 33% |
| Student > Postgraduate | 3 | 25% |
| Other | 3 | 25% |
| Student > Ph. D. Student | 1 | 8% |
| Unknown | 1 | 8% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 3 | 25% |
| Agricultural and Biological Sciences | 3 | 25% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 17% |
| Psychology | 1 | 8% |
| Physics and Astronomy | 1 | 8% |
| Other | 1 | 8% |
| Unknown | 1 | 8% |
Attention Score in Context
This research output has an Altmetric Attention Score of 23. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 August 2021.
All research outputs
#1,622,676
of 25,320,147 outputs
Outputs from Molecular Biology Reports
#24
of 3,286 outputs
Outputs of similar age
#6,780
of 120,948 outputs
Outputs of similar age from Molecular Biology Reports
#2
of 65 outputs
Altmetric has tracked 25,320,147 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,286 research outputs from this source. They receive a mean Attention Score of 2.3. This one has done particularly well, scoring higher than 99% of its peers.
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We're also able to compare this research output to 65 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.