| Title |
Susceptibility or resistance of praziquantel in human schistosomiasis: a review
|
|---|---|
| Published in |
Parasitology Research, October 2012
|
| DOI | 10.1007/s00436-012-3151-z |
| Pubmed ID | |
| Authors |
Wei Wang, Li Wang, You-Sheng Liang |
| Abstract |
Since praziquantel was developed in 1970s, it has replaced other antischistosomal drugs to become the only drug of choice for treatment of human schistosomiases, due to high efficacy, excellent tolerability, few and transient side effects, simple administration, and competitive cost. Praziquantel-based chemotherapy has been involved in the global control strategy of the disease and led to the control strategy shifting from disease control to morbidity control, which has greatly reduced the prevalence and intensity of infections. Given that the drug has been widely used for morbidity control in endemic areas for more than three decades, the emergence of resistance of Schistosoma to praziquantel under drug selection pressure has been paid much attention. It is possible to induce resistance of Schistosoma mansoni and Schistosoma japonicum to praziquantel in mice under laboratorial conditions, and a reduced susceptibility to praziquantel in the field isolates of S. mansoni has been found in many foci. In addition, there are several schistosomiasis cases caused by Schistosoma haematobium infections in which repeated standard treatment fails to clear the infection. However, in the absence of exact mechanisms of action of praziquantel, the mechanisms of drug resistance in schistosomes remain unclear. The present review mainly demonstrates the evidence of drug resistance in the laboratory and field and the mechanism of praziquantel resistance and proposes some strategies for control of praziquantel resistance in schistosomes. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 3 | 75% |
| South Africa | 1 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 75% |
| Scientists | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 377 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 6 | 2% |
| Netherlands | 1 | <1% |
| France | 1 | <1% |
| Zimbabwe | 1 | <1% |
| Switzerland | 1 | <1% |
| Ecuador | 1 | <1% |
| United Kingdom | 1 | <1% |
| Russia | 1 | <1% |
| United States | 1 | <1% |
| Other | 0 | 0% |
| Unknown | 363 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 58 | 15% |
| Student > Master | 56 | 15% |
| Student > Bachelor | 46 | 12% |
| Researcher | 42 | 11% |
| Other | 20 | 5% |
| Other | 63 | 17% |
| Unknown | 92 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 71 | 19% |
| Medicine and Dentistry | 39 | 10% |
| Biochemistry, Genetics and Molecular Biology | 37 | 10% |
| Chemistry | 35 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 21 | 6% |
| Other | 66 | 18% |
| Unknown | 108 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 14. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 February 2014.
All research outputs
#2,209,438
of 22,684,168 outputs
Outputs from Parasitology Research
#77
of 3,772 outputs
Outputs of similar age
#15,749
of 173,108 outputs
Outputs of similar age from Parasitology Research
#1
of 27 outputs
Altmetric has tracked 22,684,168 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,772 research outputs from this source. They receive a mean Attention Score of 2.7. This one has done particularly well, scoring higher than 97% of its peers.
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We're also able to compare this research output to 27 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.