| Title |
Molecular basis for chemoprevention by sulforaphane: a comprehensive review
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, March 2007
|
| DOI | 10.1007/s00018-007-6484-5 |
| Pubmed ID | |
| Authors |
N. Juge, R. F. Mithen, M. Traka |
| Abstract |
The consumption of cruciferous vegetables has long been associated with a reduced risk in the occurrence of cancer at various sites, including the prostate, lung, breast and colon. This protective effect is attributed to isothiocyanates present in these vegetables, and sulforaphane (SF), present in broccoli, is by far the most extensively studied to uncover the mechanisms behind this chemoprotection. The major mechanism by which SF protects cells was traditionally thought to be through Nrf2-mediated induction of phase 2 detoxification enzymes that elevate cell defense against oxidative damage and promote the removal of carcinogens. However, it is becoming clear that there are multiple mechanisms activated in response to SF, including suppression of cytochrome P450 enzymes, induction of apoptotic pathways, suppression of cell cycle progression, inhibition of angiogenesis and anti-inflammatory activity. Moreover, these mechanisms seem to have some degree of interaction to synergistically afford chemoprevention. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 290 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 1% |
| Portugal | 2 | <1% |
| Bangladesh | 1 | <1% |
| Malaysia | 1 | <1% |
| Canada | 1 | <1% |
| Italy | 1 | <1% |
| Mexico | 1 | <1% |
| Poland | 1 | <1% |
| Unknown | 279 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 51 | 18% |
| Student > Bachelor | 42 | 14% |
| Researcher | 41 | 14% |
| Student > Ph. D. Student | 37 | 13% |
| Student > Doctoral Student | 14 | 5% |
| Other | 42 | 14% |
| Unknown | 63 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 85 | 29% |
| Biochemistry, Genetics and Molecular Biology | 36 | 12% |
| Medicine and Dentistry | 30 | 10% |
| Chemistry | 21 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 10 | 3% |
| Other | 37 | 13% |
| Unknown | 71 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 19. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 February 2016.
All research outputs
#1,766,123
of 23,794,258 outputs
Outputs from Cellular and Molecular Life Sciences
#185
of 4,151 outputs
Outputs of similar age
#3,793
of 78,509 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#3
of 38 outputs
Altmetric has tracked 23,794,258 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,151 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 78,509 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 38 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.