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Mendeley readers
Attention Score in Context
| Title |
Oncogenic microtubule hyperacetylation through BEX4-mediated sirtuin 2 inhibition
|
|---|---|
| Published in |
Cell Death & Disease, August 2016
|
| DOI | 10.1038/cddis.2016.240 |
| Pubmed ID | |
| Authors |
Jin-Kwan Lee, Janet Lee, Heounjeong Go, Chang Geun Lee, Suhyeon Kim, Hyun-Soo Kim, Hyeseong Cho, Kyeong Sook Choi, Geun-Hyoung Ha, Chang-Woo Lee |
| Abstract |
Five brain-expressed X-linked (BEX) gene members (BEX1-5) are arranged in tandem on chromosome X, and are highly conserved across diverse species. However, little is known about the function and role of BEX. This study represents a first attempt to demonstrate the molecular details of a novel oncogene BEX4. Among BEX proteins, BEX4 localizes to microtubules and spindle poles, and interacts with α-tubulin (α-TUB) and sirtuin 2 (SIRT2). The overexpression of BEX4 leads to the hyperacetylation of α-TUB by inhibiting SIRT2-mediated deacetylation. Furthermore, we found BEX4 expression conferred resistance to apoptotic cell death but led to acquisition of aneuploidy, and also increased the proliferating potential and growth of tumors. These results suggest that BEX4 overexpression causes an imbalance between TUB acetylation and deacetylation by SIRT2 inhibition and induces oncogenic aneuploidy transformation. |
Mendeley readers
The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 21 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 4 | 19% |
| Student > Ph. D. Student | 4 | 19% |
| Student > Doctoral Student | 2 | 10% |
| Professor > Associate Professor | 2 | 10% |
| Professor | 1 | 5% |
| Other | 3 | 14% |
| Unknown | 5 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 7 | 33% |
| Agricultural and Biological Sciences | 3 | 14% |
| Medicine and Dentistry | 3 | 14% |
| Chemistry | 1 | 5% |
| Unspecified | 1 | 5% |
| Other | 0 | 0% |
| Unknown | 6 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 March 2022.
All research outputs
#3,051,116
of 23,460,553 outputs
Outputs from Cell Death & Disease
#752
of 6,650 outputs
Outputs of similar age
#56,023
of 358,147 outputs
Outputs of similar age from Cell Death & Disease
#21
of 82 outputs
Altmetric has tracked 23,460,553 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 6,650 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.2. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 358,147 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 82 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.