| Title |
Association between maternal nutritional status in pregnancy and offspring cognitive function during childhood and adolescence; a systematic review
|
|---|---|
| Published in |
BMC Pregnancy and Childbirth, August 2016
|
| DOI | 10.1186/s12884-016-1011-z |
| Pubmed ID | |
| Authors |
Sargoor R. Veena, Catharine R. Gale, Ghattu V. Krishnaveni, Sarah H Kehoe, Krishnamachari Srinivasan, Caroline HD Fall |
| Abstract |
The mother is the only source of nutrition for fetal growth including brain development. Maternal nutritional status (anthropometry, macro- and micro-nutrients) before and/or during pregnancy is therefore a potential predictor of offspring cognitive function. The relationship of maternal nutrition to offspring cognitive function is unclear. This review aims to assess existing evidence linking maternal nutritional status with offspring cognitive function. Exposures considered were maternal BMI, height and weight, micronutrient status (vitamins D, B12, folate and iron) and macronutrient intakes (carbohydrate, protein and fat). The outcome was any measure of cognitive function in children aged <18 years. We considered observational studies and trials with allocation groups that differed by single nutrients. We searched Medline/PubMed and the Cochrane Library databases and reference lists of retrieved literature. Two reviewers independently extracted data from relevant articles. We used methods recommended by the Centre for Reviews and Dissemination, University of York and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Of 16,143 articles identified, 38 met inclusion criteria. Most studies were observational, and from high-income settings. There were few randomized controlled trials. There was consistent evidence linking maternal obesity with lower cognitive function in children; low maternal BMI has been inadequately studied. Among three studies of maternal vitamin D status, two showed lower cognitive function in children of deficient mothers. One trial of folic acid supplementation showed no effects on the children's cognitive function and evidence from 13 observational studies was mixed. Among seven studies of maternal vitamin B12 status, most showed no association, though two studies in highly deficient populations suggested a possible effect. Four out of six observational studies and two trials (including one in an Iron deficient population) found no association of maternal iron status with offspring cognitive function. One trial of maternal carbohydrate/protein supplementation showed no effects on offspring cognitive function. Current evidence that maternal nutritional status during pregnancy as defined by BMI, single micronutrient studies, or macronutrient intakes influences offspring cognitive function is inconclusive. There is a need for more trials especially in populations with high rates of maternal undernutrition. Registered in PROSPERO CRD42013005702 . |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 2 | 67% |
| Comoros | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Scientists | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 503 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 1 | <1% |
| Unknown | 502 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 72 | 14% |
| Student > Bachelor | 69 | 14% |
| Researcher | 52 | 10% |
| Student > Ph. D. Student | 51 | 10% |
| Student > Postgraduate | 19 | 4% |
| Other | 78 | 16% |
| Unknown | 162 | 32% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 95 | 19% |
| Nursing and Health Professions | 71 | 14% |
| Biochemistry, Genetics and Molecular Biology | 29 | 6% |
| Psychology | 27 | 5% |
| Agricultural and Biological Sciences | 22 | 4% |
| Other | 72 | 14% |
| Unknown | 187 | 37% |
Attention Score in Context
This research output has an Altmetric Attention Score of 18. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 January 2018.
All research outputs
#1,705,653
of 22,882,389 outputs
Outputs from BMC Pregnancy and Childbirth
#425
of 4,210 outputs
Outputs of similar age
#33,469
of 355,875 outputs
Outputs of similar age from BMC Pregnancy and Childbirth
#11
of 104 outputs
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So far Altmetric has tracked 4,210 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.8. This one has done well, scoring higher than 89% of its peers.
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