| Title |
Combined exposure to Maneb and Paraquat alters transcriptional regulation of neurogenesis-related genes in mice models of Parkinson’s disease
|
|---|---|
| Published in |
Molecular Neurodegeneration, September 2012
|
| DOI | 10.1186/1750-1326-7-49 |
| Pubmed ID | |
| Authors |
Paula Desplats, Pruthul Patel, Kori Kosberg, Michael Mante, Christina Patrick, Edward Rockenstein, Masayo Fujita, Makoto Hashimoto, Eliezer Masliah |
| Abstract |
Parkinson's disease (PD) is a multifactorial disease where environmental factors act on genetically predisposed individuals. Although only 5% of PD manifestations are associated with specific mutations, majority of PD cases are of idiopathic origin, where environment plays a prominent role. Concurrent exposure to Paraquat (PQ) and Maneb (MB) in rural workers increases the risk for PD and exposure of adult mice to MB/PQ results in dopamine fiber loss and decreased locomotor activity. While PD is characterized by neuronal loss in the substantia nigra, we previously showed that accumulation of α-synuclein in the limbic system contributes to neurodegeneration by interfering with adult neurogenesis. |
Mendeley readers
The data shown below were compiled from readership statistics for 80 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 3% |
| Portugal | 1 | 1% |
| Unknown | 77 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 15 | 19% |
| Student > Ph. D. Student | 15 | 19% |
| Student > Bachelor | 13 | 16% |
| Student > Master | 11 | 14% |
| Other | 4 | 5% |
| Other | 12 | 15% |
| Unknown | 10 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 18 | 23% |
| Medicine and Dentistry | 15 | 19% |
| Neuroscience | 14 | 18% |
| Biochemistry, Genetics and Molecular Biology | 6 | 8% |
| Psychology | 4 | 5% |
| Other | 10 | 13% |
| Unknown | 13 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 September 2012.
All research outputs
#22,758,309
of 25,373,627 outputs
Outputs from Molecular Neurodegeneration
#960
of 977 outputs
Outputs of similar age
#171,740
of 191,377 outputs
Outputs of similar age from Molecular Neurodegeneration
#9
of 12 outputs
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