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Lipocalin‐2 ameliorates granulocyte functionality

Overview of attention for article published in European Journal of Immunology, November 2012
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Title
Lipocalin‐2 ameliorates granulocyte functionality
Published in
European Journal of Immunology, November 2012
DOI 10.1002/eji.201142351
Pubmed ID
Authors

Andrea Schroll, Kathrin Eller, Clemens Feistritzer, Manfred Nairz, Thomas Sonnweber, Patrizia A. Moser, Alexander R. Rosenkranz, Igor Theurl, Guenter Weiss

Abstract

Attraction of neutrophils to sites of infection or tissue injury is an essential prerequisite for an efficient innate immune response. Herein, we provide novel evidence that the antimicrobial protein, neutrophil gelatinase associated lipocalin (24p3 or lipocalin-2, Lcn2) is a central regulator of this process. Lcn2 is produced by several cell types but high amounts are released by neutrophils. Using human and murine neutrophils, we found that the addition of recombinant Lcn2 significantly stimulated their migration, which was independent of IL-8/keratinocyte chemokine formation. Mechanistically, this could be traced back to Lcn2-mediated changes of Erk1/2 signaling. Accordingly, the i.p. injection of Lcn2 into C57BL/6 mice stimulated the mobilization of neutrophils while we found a significantly reduced neutrophil chemotactic activity of cells obtained from Lcn2 KO mice. This observation transmitted to a reduced accumulation of neutrophils in intra-dermal lesions infected with Salmonella typhimurium in Lcn2 KO mice as compared to WT mice. This was not only due to a reduced chemotaxis but also to an impaired cellular adhesion of neutrophils in the absence of Lcn2. We herein describe a novel role of Lcn2 as an important paracrine chemoattractant and an indispensable factor for neutrophil function in inflammation.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 62 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 2%
Unknown 61 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 15 24%
Researcher 11 18%
Student > Master 9 15%
Student > Bachelor 8 13%
Student > Doctoral Student 3 5%
Other 9 15%
Unknown 7 11%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 14 23%
Medicine and Dentistry 13 21%
Agricultural and Biological Sciences 11 18%
Immunology and Microbiology 7 11%
Pharmacology, Toxicology and Pharmaceutical Science 2 3%
Other 4 6%
Unknown 11 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 November 2012.
All research outputs
#16,744,582
of 24,629,540 outputs
Outputs from European Journal of Immunology
#5,847
of 6,823 outputs
Outputs of similar age
#120,463
of 187,742 outputs
Outputs of similar age from European Journal of Immunology
#17
of 41 outputs
Altmetric has tracked 24,629,540 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 6,823 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.2. This one is in the 8th percentile – i.e., 8% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 187,742 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 41 others from the same source and published within six weeks on either side of this one. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.