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Effect of a Monoclonal Antibody to PCSK9 on Low-Density Lipoprotein Cholesterol Levels in Statin-Intolerant Patients: The GAUSS Randomized Trial

Overview of attention for article published in JAMA: Journal of the American Medical Association, December 2012
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (97th percentile)
  • Good Attention Score compared to outputs of the same age and source (78th percentile)

Citations

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398 Dimensions

Readers on

mendeley
255 Mendeley
citeulike
2 CiteULike
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Title
Effect of a Monoclonal Antibody to PCSK9 on Low-Density Lipoprotein Cholesterol Levels in Statin-Intolerant Patients: The GAUSS Randomized Trial
Published in
JAMA: Journal of the American Medical Association, December 2012
DOI 10.1001/jama.2012.25790
Pubmed ID
Authors

David Sullivan, Anders G. Olsson, Rob Scott, Jae B. Kim, Allen Xue, Val Gebski, Scott M. Wasserman, Evan A. Stein

Abstract

An estimated 10% to 20% of patients cannot tolerate statins or adequate doses to achieve treatment goals. Plasma proprotein convertase subtilisin/kexin type 9 (PCSK9) binds to low-density lipoprotein (LDL) receptors, promoting their degradation and increasing LDL cholesterol levels. In phase 1 studies, a human monoclonal antibody to PCSK9, AMG145, was well tolerated and reduced LDL cholesterol levels.

X Demographics

X Demographics

The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 255 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 2 <1%
United States 2 <1%
Italy 1 <1%
Austria 1 <1%
Egypt 1 <1%
United Kingdom 1 <1%
Japan 1 <1%
Mexico 1 <1%
Unknown 245 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 39 15%
Student > Ph. D. Student 28 11%
Student > Bachelor 26 10%
Other 24 9%
Student > Master 24 9%
Other 60 24%
Unknown 54 21%
Readers by discipline Count As %
Medicine and Dentistry 106 42%
Agricultural and Biological Sciences 24 9%
Pharmacology, Toxicology and Pharmaceutical Science 20 8%
Biochemistry, Genetics and Molecular Biology 16 6%
Nursing and Health Professions 6 2%
Other 18 7%
Unknown 65 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 41. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 February 2022.
All research outputs
#995,898
of 25,371,288 outputs
Outputs from JAMA: Journal of the American Medical Association
#8,407
of 36,409 outputs
Outputs of similar age
#7,837
of 288,477 outputs
Outputs of similar age from JAMA: Journal of the American Medical Association
#40
of 190 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 36,409 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 72.5. This one has done well, scoring higher than 76% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 288,477 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 190 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 78% of its contemporaries.