| Title |
The Unique Evolutionary Signature of Genes Associated with Autism Spectrum Disorder
|
|---|---|
| Published in |
Behavior Genetics, August 2016
|
| DOI | 10.1007/s10519-016-9804-4 |
| Pubmed ID | |
| Authors |
Erez Tsur, Michael Friger, Idan Menashe |
| Abstract |
Autism spectrum disorder (ASD) is a common heritable neurodevelopmental disorder, which is characterized by communication and social deficits that reduce the reproductive fitness of individuals with the disorder. Here, we studied the genomic characteristics of 651 ASD genes in a whole-exome sequencing dataset, to search for traces of the evolutionary forces that helped maintain ASD in the human population. We show that ASD genes are ~65 longer and ~20 % less variable than non-ASD genes. The mutational shortage in ASD genes was particularly eminent when considering only deleterious genetic variations, which is a hallmark of negative selection. We further show that these genomic characteristics are unique to ASD genes, as compared with brain-specific genes or with genes of other diseases. Our findings suggest that ASD genes have evolved under complex evolutionary forces, which have left a unique signature that can be used to identify new candidate ASD genes. |
X Demographics
The data shown below were collected from the profiles of 13 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 15% |
| Switzerland | 1 | 8% |
| Israel | 1 | 8% |
| Russia | 1 | 8% |
| United Kingdom | 1 | 8% |
| Unknown | 7 | 54% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 11 | 85% |
| Science communicators (journalists, bloggers, editors) | 1 | 8% |
| Scientists | 1 | 8% |
Mendeley readers
The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 42 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 7 | 17% |
| Student > Ph. D. Student | 5 | 12% |
| Student > Master | 5 | 12% |
| Student > Bachelor | 5 | 12% |
| Other | 4 | 10% |
| Other | 9 | 21% |
| Unknown | 7 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 7 | 17% |
| Agricultural and Biological Sciences | 6 | 14% |
| Medicine and Dentistry | 5 | 12% |
| Computer Science | 4 | 10% |
| Biochemistry, Genetics and Molecular Biology | 3 | 7% |
| Other | 7 | 17% |
| Unknown | 10 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 45. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 August 2018.
All research outputs
#944,715
of 25,732,188 outputs
Outputs from Behavior Genetics
#41
of 974 outputs
Outputs of similar age
#17,925
of 370,709 outputs
Outputs of similar age from Behavior Genetics
#1
of 17 outputs
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