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X Demographics
Mendeley readers
Attention Score in Context
| Title |
A Core Metabolic Enzyme Mediates Resistance to Phosphine Gas
|
|---|---|
| Published in |
Science, November 2012
|
| DOI | 10.1126/science.1224951 |
| Pubmed ID | |
| Authors |
David I. Schlipalius, Nicholas Valmas, Andrew G. Tuck, Rajeswaran Jagadeesan, Li Ma, Ramandeep Kaur, Anita Goldinger, Cameron Anderson, Jujiao Kuang, Steven Zuryn, Yosep S. Mau, Qiang Cheng, Patrick J. Collins, Manoj K. Nayak, Horst Joachim Schirra, Massimo A. Hilliard, Paul R. Ebert |
| Abstract |
Phosphine is a small redox-active gas that is used to protect global grain reserves, which are threatened by the emergence of phosphine resistance in pest insects. We find that polymorphisms responsible for genetic resistance cluster around the redox-active catalytic disulfide or the dimerization interface of dihydrolipoamide dehydrogenase (DLD) in insects (Rhyzopertha dominica and Tribolium castaneum) and nematodes (Caenorhabditis elegans). DLD is a core metabolic enzyme representing a new class of resistance factor for a redox-active metabolic toxin. It participates in four key steps of core metabolism, and metabolite profiles indicate that phosphine exposure in mutant and wild-type animals affects these steps differently. Mutation of DLD in C. elegans increases arsenite sensitivity. This specific vulnerability may be exploited to control phosphine-resistant insects and safeguard food security. |
X Demographics
The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 3 | 38% |
| United Kingdom | 2 | 25% |
| Australia | 1 | 13% |
| United States | 1 | 13% |
| Unknown | 1 | 13% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 8 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 103 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | <1% |
| United Kingdom | 1 | <1% |
| Singapore | 1 | <1% |
| Japan | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 98 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 27 | 26% |
| Student > Ph. D. Student | 20 | 19% |
| Student > Bachelor | 13 | 13% |
| Student > Master | 9 | 9% |
| Student > Postgraduate | 6 | 6% |
| Other | 15 | 15% |
| Unknown | 13 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 54 | 52% |
| Biochemistry, Genetics and Molecular Biology | 10 | 10% |
| Medicine and Dentistry | 5 | 5% |
| Chemistry | 5 | 5% |
| Engineering | 2 | 2% |
| Other | 9 | 9% |
| Unknown | 18 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 19. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 September 2020.
All research outputs
#1,865,043
of 24,588,574 outputs
Outputs from Science
#25,749
of 79,897 outputs
Outputs of similar age
#12,180
of 186,294 outputs
Outputs of similar age from Science
#292
of 761 outputs
Altmetric has tracked 24,588,574 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 79,897 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 64.5. This one has gotten more attention than average, scoring higher than 67% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 186,294 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 761 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.